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Title Advances in mitochondrial medicine / Roberto Scatena, Patrizia Bottoni, Bruno Giardina, editors
Published Dordrecht ; New York : Springer, [2012]
©2012
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Description 1 online resource (xii, 461 pages)
Series Advances in experimental medicine and biology, 0065-2598 ; 942
Advances in experimental medicine and biology ; 942
Contents Part 1. Physiology and structure of Mitochondria / The Oxidative Phosphorylation System in Mammalian Mitochondria / Sergio Papa, Pietro Luca Martino, Giuseppe Capitanio, Antonio Gaballo and Domenico De Rasmo, et al. -- Physiology and Pathophysiology of Mitochondrial DNA / Hongzhi Li, Danhui Liu, Jianxin Lu and Yidong Bai -- Mitochondrial Ca2+ as a Key Regulator of Mitochondrial Activities / Tito Calì, Denis Ottolini and Marisa Brini -- Mitochondria and Nitric Oxide: Chemistry and Pathophysiology / Paolo Sarti, Marzia Arese, Elena Forte, Alessandro Giuffrè and Daniela Mastronicola -- Mitochondria and Reactive Oxygen Species. Which Role in Physiology and Pathology? / Giorgio Lenaz -- Uncoupling Proteins: Molecular, Functional, Regulatory, Physiological and Pathological Aspects / Francis E. Sluse -- The Mitochondrial Pathways of Apoptosis / Jérome Estaquier, François Vallette, Jean-Luc Vayssiere and Bernard Mignotte -- Part 2. Mitochondria and disease / Inherited Mitochondrial Disorders / Josef Finsterer -- Role of Mitochondrial Function in Insulin Resistance / Myrte Brands, Arthur J. Verhoeven and Mireille J. Serlie -- Mitochondria and Diabetes. An Intriguing Pathogenetic Role / Philip Newsholme, Celine Gaudel and Maurico Krause -- Mitochondria and Heart Disease / Elinor J. Griffiths -- Mitochondria in Neurodegeneration / E Lezi and Russell H. Swerdlow -- Mitochondria and Cancer: A Growing Role in Apoptosis, Cancer Cell Metabolism and Dedifferentiation / Roberto Scatena -- Part 3. Mitochondria and Aging / Mitochondria and Aging / Hsin-Chen Lee and Yau-Huei Wei -- Mitochondria and Drugs / Roberto Scatena -- Iatrogenic Mitochondriopathies: A Recent Lesson from Nucleoside/Nucleotide Reverse Transcriptase Inhibitors / George P.H. Leung -- Dysfunction of Mitochondrial Respiratory Chain Complex I in Neurological Disorders: Genetics and Pathogenetic Mechanisms / Vittoria Petruzzella, Anna Maria Sardanelli, Salvatore Scacco, Damiano Panelli and Francesco Papa, et al. -- Anthracyclines and Mitochondria / Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini, Giuseppe Ettore Martorana and Bruno Giardina -- Mitochondrial Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers in Cancer / Patrizia Bottoni, Bruno Giardina, Alessandro Pontoglio, Salvatore Scarà and Roberto Scatena -- Mitochondria in Anthropology and Forensic Medicine / Tomasz Grzybowski and Urszula Rogalla
Summary Mitochondria are far more than the powerhouse of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of mitochondrial medicine, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called mitoxicants are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology
Analysis Medicine
Oncology
Toxicology
Biochemistry
Biomedicine
Cancer Research
Molecular Medicine
Pharmacology/Toxicology
Medical Biochemistry
Bibliography Includes bibliographical references and index
Notes English
Subject Mitochondrial pathology.
Metabolic Diseases.
Biological Science Disciplines.
Organelles.
Subcellular Fractions.
Cytoplasmic Structures.
Natural Science Disciplines.
Nutritional and Metabolic Diseases.
Cellular Structures.
Cells.
Disease.
Disciplines and Occupations
Cytoplasm.
Intracellular Space.
Anatomy.
Mitochondria.
Physiology.
Mitochondrial Diseases.
Form Electronic book
Author Scatena, Roberto.
Bottoni, Patrizia.
Giardina, B. (Bruno), 1945-
LC no. 2011945106
ISBN 9789400728691 (electronic bk.)
9400728697 (electronic bk.)
9400728689
9789400728684