Limit search to available items
44 results found. Sorted by relevance | date | title .
Book Cover
E-book
Author Cipolla, Marilyn J

Title The cerebral circulation / Marilyn J. Cipolla
Published [San Rafael, CA] : Morgan & Claypool Life Sciences, ©2010

Copies

Description 1 online resource (1online resource (1 PDF file (x, 59a pages : illustrations)))
Series Integrated systems physiology : from molecules to function ; #2
Colloquium series on integrated systems physiology ; #2. 2154-5626
Contents 1. Introduction -- 2. Anatomy and ultrastructure -- The arteries -- Cerebral vascular architecture -- The veins -- Structure of cerebral vessels -- The microcirculation and the "neurovascular unit" -- Pericytes -- Collaterals
Summary This presentation describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands, and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic, and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death
Bibliography Includes bibliographical references
Notes English
Subject Cerebral circulation.
Cerebrovascular Circulation -- physiology
Brain -- blood supply
Blood-Brain Barrier -- physiology
Homeostasis -- physiology
Cerebrovascular Circulation
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Cerebral circulation
Form Electronic book
ISBN 9781615040124
1615040129
9781615040131
1615040137
Other Titles Colloquium digital library of life sciences: Collection 1
NCBI Bookshelf