| Description |
1 online resource |
| Series |
Advances in experimental medicine and biology, 0065-2598 ; v. 786 |
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Advances in experimental medicine and biology ; v. 786.
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| Contents |
Model Stem Cell Systems (A) Invertebrate. Germline Stem Cells and Their Regulation in the Nematode Caenorhabditis elegans / Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter -- Transcriptional and Post-transcriptional Regulation of Drosophila Germline Stem Cells and Their Differentiating Progeny / Helen White-Cooper, Simona Caporilli -- Stem Cells in the Drosophila Digestive System / Xiankun Zeng, Chhavi Chauhan, Steven X. Hou -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System / Rita Sousa-Nunes, W. Gregory Somers |
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Model Stem Cell Systems (B) Vertebrate. Transcriptional/Translational Regulation of Mammalian Spermatogenic Stem Cells / Cathryn A. Hogarth -- Transcriptional Regulation and Specification of Neural Stem Cells / Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate -- Transcriptional Control of Epidermal Stem Cells / Briana Lee, Xing Dai -- Regulation of Intestinal Stem Cells by Wnt and Notch Signalling / Katja Horvay, Helen E. Abud -- Transcriptional Regulation of Haematopoietic Stem Cells / Adam C. Wilkinson, Berthold Göttgens -- Regulation of Mesenchymal Stem Cell Differentiation / David Cook, Paul Genever |
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Molecular Families Implicated in Stem Cell Regulation. The Musashi Family of RNA Binding Proteins: Master Regulators of Multiple Stem Cell Populations / Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime, Nicole A. Siddall -- JAK-STAT Signaling in Stem Cells / Rachel R. Stine, Erika L. Matunis -- Myc in Stem Cell Behaviour: Insights from Drosophila / Leonie M. Quinn, Julie Secombe, Gary R. Hime -- The Role of Nuclear Receptors in Embryonic Stem Cells / Qin Wang, Austin J. Cooney -- Epigenetic Regulation of Stem Cells / Anton Wutz -- Regulation of Stem Cell Populations by microRNAs / Julie Mathieu, Hannele Ruohola-Baker -- Myb and the Regulation of Stem Cells in the Intestine and Brain: A Tale of Two Niches / Jordane Malaterre, Lloyd Pereira, Robert G. Ramsay -- The Stem Cell State / Gary R. Hime, Helen E. Abud -- Induction of Pluripotency / Corey Heffernan, Jun Liu, Huseyin Sumer |
| Summary |
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes - achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different s |
| Analysis |
Medicine |
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Cytology |
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Stem cells |
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Developmental biology |
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Biomedicine |
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Cell Biology |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Stem cells.
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Cellular control mechanisms.
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Stem Cells
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Molecular Biology
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MEDICAL -- Research.
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Cellular control mechanisms
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Stem cells
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| Form |
Electronic book
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| Author |
Hime, Gary
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Abud, Helen
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| ISBN |
9789400766211 |
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9400766211 |
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