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Author Kameo, Yoshitaka, author

Title Bone adaptation : in silico approach / Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
Published Tokyo, Japan : Springer, 2018
Online access available from:
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Description 1 online resource
Series Frontiers of biomechanics ; volume 2
Frontiers of biomechanics ; v. 2
Contents Intro; Preface; Contents; Chapter 1: Overview: In Silico Approaches to Understand Bone Adaptation; 1.1 Introduction; 1.2 Modeling Bone Adaptation from Cellular to Tissue Level; 1.3 Modeling Bone Adaptation from Tissue to Organ Level; 1.4 Open Questions and Future Directions; 1.4.1 Osteocyte Mechanotransduction; 1.4.2 Osteocyte Morphology; 1.4.3 Signaling in Bone Metabolism; 1.5 Conclusion; References; Chapter 2: Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus; 2.1 Introduction; 2.2 Three-Dimensional Reconstruction of Osteocytes in Canaliculi; 2.3 Computational Fluid Flow Analysis
2.4 Model of Osteocyte Canaliculi2.5 Interstitial Fluid Flow in Osteocyte Canaliculi; 2.6 Importance of Canalicular Microstructure in Osteocyte Mechanosensing; 2.7 Conclusion; References; Chapter 3: Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula; 3.1 Introduction; 3.2 Theory of Poroelasticity; 3.2.1 Constitutive Relations; 3.2.2 Governing Equations; 3.3 Poroelastic Modeling of a Single Trabecula; 3.3.1 Formulation of Poroelastic Problem; 3.3.2 Analytical Solution for Fluid Pressure; 3.4 Interstitial Fluid Pressure in Trabecula; 3.4.1 Description of Fluid Pressure Behavior
3.4.2 Steady-State Response3.4.3 Transient Response; 3.5 Importance of Transient Fluid Pressure Response; 3.6 Implications of Fluid Flow in Trabecular Bone Remodeling; 3.7 Conclusion; References; Chapter 4: Estimation of Bone Permeability for Poroelastic Analysis; 4.1 Introduction; 4.2 Confocal Laser Scanning Imaging of Lacuno-Canalicular Porosity; 4.3 Theoretical Method for Estimating Bone Permeability; 4.3.1 Quantification of Canalicular Anisotropy; 4.3.2 Estimation of Trabecular Bone Permeability; 4.4 Application to Confocal Laser Scanning Imaging
4.4.1 Quantification of Canalicular Anisotropy4.4.2 Estimation of Trabecular Bone Permeability; 4.5 Validation of the Estimated Bone Permeability; 4.6 Characteristics of the Proposed Estimation Method; 4.7 Conclusion; References; Chapter 5: Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes; 5.1 Introduction; 5.2 Mathematical Model of Trabecular Bone Remodeling; 5.2.1 Theoretical Framework; 5.2.2 Cellular Mechanosensing; 5.2.3 Intercellular Signal Transmission; 5.2.4 Trabecular Surface Movement; 5.3 Voxel Modeling of a Single Trabecula under Cyclic Uniaxial Load
5.4 Adaptation of a Single Trabecula to Cyclic Uniaxial Load5.4.1 Morphological Changes in Trabecula; 5.4.2 Quantitative Evaluation of Remodeling Process; 5.5 Characteristics of the Proposed Remodeling Model; 5.6 Validity of the Simulated Remodeling Process; 5.7 Conclusion; References; Chapter 6: Effects of Local Bending Load on Trabecular Bone Adaptation; 6.1 Introduction; 6.2 Voxel Modeling of a Single Trabecula under a Cyclic Bending Load; 6.3 Adaptation of a Single Trabecula to a Cyclic Bending Load; 6.4 Role of Local Bending Load in Bone Remodeling; 6.5 Conclusion; References
Summary This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics
Bibliography Includes bibliographical references and index
Subject Bones -- Adaptation.
Form Electronic book
Author Adachi, Taiji, author
Tsubota, Ken-ichi, author
ISBN 4431565140 (electronic bk.)
9784431565147 (electronic bk.)