Title Advancing disease modeling in animal-based research in support of precision medicine : proceedings of a workshop / Erin Hammers Forstag and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division of Earth and Life Studies, the National Academies of Sciences, Engineering, Medicine

Published Washington, DC : The National Academies Press, [2018] ©2018

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Description 1 online resource (xiii, 122 pages) : color illustrations Contents Introduction to precision medicine and animal models -- Existing precision medicine initiatives -- The promise and perils of animal models -- Reproducibility and predictivity -- In vitro alternatives to animal models -- Assessing safety and toxicology -- Patient perspectives -- Reflections on the workshop -- References Summary "Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop"--Publisher's description Bibliography Includes bibliographical references (pages 90-94) Notes Online resource; title from PDF title page (National Academies Press, viewed June 4, 2018) Subject Animal models in research -- Congresses Precision medicine -- Congresses Precision medicine Diseases -- Animal models. Precision Medicine Disease Models, Animal Research Design HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Diseases -- Animal models Animal models in research Precision medicine Genre/Form Electronic books proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Anestidou, Lida, 1965- rapporteur. Institute for Laboratory Animal Research (U.S.). Roundtable on Science and Welfare in Laboratory Animal Use, issuing body. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine (Workshop) (2017 : Washington, D.C.), author. ISBN 9780309471190 0309471192 9780309471176 0309471176

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