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Title Epigenetics in psychiatry / edited by Jacob Peedicayil, Dennis R. Grayson, Dimitrios Avramopoulos
Published San Diego, CA : Academic Press, [2014]
Online access available from:
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Description 1 online resource (664 pages)
Contents Front Cover; Epigenetics in Psychiatry; Copyright Page; Contents; Preface; About the Editors; List of Contributors; 1 General Aspects of Epigenetics in Psychiatry; 1 Introduction to Epigenetics in Psychiatry; Introduction; Genetics of psychiatric disorders; Schizophrenia; Autism spectrum disorder; Bipolar disorder; Major depressive disorder; Attention deficit hyperactivity disorder; Genotype versus phenotype; Missing heritability; Epigenetics in psychiatric disorders; Nutrition; Prenatal infection; Stress; Epigenetic versus genetic approaches to psychiatric disorders
Concluding remarksAcknowledgments; References; Glossary; 5 Role of Epigenetics in the Brain; Introduction; Role of epigenetics in evolution; Role of epigenetics in brain development; Brain development; Epigenetics in early brain development; Epigenetics in adult neurogenesis and later brain maturation; Epigenetics and extrinsic factors regulating brain development; Role of epigenetic mechanisms in brain function; Epigenetics and memory; Epigenetics and stress; Epigenetics and cognitive dysfunction; Concluding remarks; Acknowledgments; References; Glossary
Epigenetic regulation underlying properties of multipotent neural stem cells and their differentiation into upper layer cor ...Epigenetic regulation of postnatal oligodendrocyte differentiation and adult neurogenesis; Combination of trans-acting epigenetic modifiers involved in epigenome formation; Importance of focusing on epigenetics in neuronal functions; Impact of epigenetic regulation on synaptic plasticity, learning, and memory; Plasticity of epigenetic profile in neurons in response to extrinsic stimuli; The robust identity of neurons defined by the epigenetic status
Erikson's epigenetic principleSchizophrenia: the epigenetic puzzle; Later theoretical developments; Experimental (laboratory) studies on epigenetics in psychiatry; The social environment and epigenetics in psychiatry; Conclusions; References; Glossary; 4 Roles of Epigenetics in the Neural Stem Cell and Neuron; Outline of neural cell production during cortical development; Epigenetic regulation of exit from cell proliferation cycle toward postmitotic neurons during early cortical development
Moving epigenetics forwardConclusion; References; Glossary; 2 Outline of Epigenetics; Introduction; Molecular mechanisms of epigenetics; DNA methylation; DNA methylation, development, and disease; Chromatin remodeling and histone modifications; Histone acetylation; Histone methylation; Other histone modifications; Non-Coding RNA; microRNA; Correlation of epigenetics with genetics, transcriptomics, and proteomics; Clinical and medical implication of epigenetics; Conclusion; Acknowledgments; References; Glossary; 3 A Brief History of Epigenetics in Psychiatry; Introduction
Summary Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles o
Notes Includes index
Description based on print version record
Subject Mental illness -- Etiology.
Mental illness -- Pathophysiology.
Form Electronic book
Author Avramopoulos, Dimitri
Grayson, Dennis R
Peedicayil, Jacob.
ISBN 0124171141
0124171346 (electronic bk.)
1306902541 (ebk)
9780124171343 (electronic bk.)
9781306902540 (ebk)