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Title The hippo signaling pathway and cancer / Moshe Oren, Yael Aylon, editors
Published New York, NY : Springer, ©2013

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Description 1 online resource
Contents Up-stream Components of Hippo Signaling -- Merlin and Angiomotin in Hippo-Yap Signaling / Chunling Yi, Joseph Kissil -- MST1/2 and Other Upstream Signaling that Affect Hippo Pathway Function / Julien Fitamant [and others] -- YAP and TAZ -- YAP1 Uses Its Modular Protein Domains and Conserved Sequence Motifs to Orchestrate Diverse Repertoires of Signaling / Marius Sudol, Irwin H. Gelman, Jianmin Zhang -- Regulation of YAP and TAZ Transcription Co-activators / Fa-Xing Yu, Bin Zhao, Kun-Liang Guan -- Regulation of YAP and TAZ by Epithelial Plasticity / Stefano Piccolo, Michelangelo Cordenonsi -- Apoptosis and Hippo Signaling -- Hippo Pathway and Apoptosis / Garth Hamilton, Eric O'Neill -- YAP and p73: A Matter of Mutual Specificity in Tumor Suppression / Sara Donzelli, Sabrina Strano, Giovanni Blandino -- The c-Abl/YAP/p73 Apoptotic Module and the HIPPO Pathway / Nina Reuven, Yosef Shaul -- Cell Cycle and Hippo Signaling -- Hippo in Cell Cycle and Mitosis / Norikazu Yabuta, Hiroshi Nojima -- Mouse Models -- Hippo and Mouse Models for Cancer / Min-Chul Kim [and others] -- Roles of Hippo Signaling During Mouse Embryogenesis / Hiroshi Sasaki -- Hippo Signaling and Stem Cells / Kriti Shrestha, Fernando D. Camargo -- Hippo Signaling and Organ Size Control / Randy L. Johnson -- Hippo Signaling in Heart Development / Todd Heallen [and others] -- Cross-Talk with Other Pathways -- Cell Competition and the Hippo Pathway / Chiao-Lin Chen, Georg Halder -- Non-canonical Roles for the Hippo Pathway / Xaralabos Varelas
Summary The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book
Analysis Medicine
Oncology
Microbiology
Cytology
Biomedicine
Cancer Research
Cell Biology
Medical Microbiology
Notes Includes index
Bibliography Cludes bibliographical references
Notes English
In Springer eBooks
Subject Cancer -- Genetic aspects.
Cellular signal transduction.
Cancer -- Molecular aspects.
Cell Transformation, Neoplastic
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Signal Transduction
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cancer -- Genetic aspects
Cancer -- Molecular aspects
Cellular signal transduction
Form Electronic book
Author Oren, Moshe
Aylon, Yael
ISBN 9781461462200
1461462207