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Book Cover
Author Serhan, Charles N.

Title Fundamentals of Inflammation
Published Cambridge : Cambridge University Press, 2010
Online access available from:
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Description 1 online resource (489 pages)
Contents Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Part I. The Inflammatory Response -- an Overview; 1 Acute and Chronic Inflammation; Introduction; The Acute Inflammatory Response; Regulation of the Acute Inflammatory Response; The Complement Cascade; Intercommunications between Inflammatory Cascades and the Coagulation Cascade; Outcomes of the Acute Inflammatory Response and Disordered Responses; Functional Consequences of the Acute Inflammatory Response; Granulomatosis Inflammation; Chronic Inflammation; Therapeutic Interventions in Inflammation; Acknowledgments
Immune RecognitionImmune Effectors; Immune Counter-Regulation; Relationship between Acute versus Chronic Inflammation and Innate versus Adaptive Immunity; Regulation of Adaptive Immunity by the Innate Immune System; Activation of Adaptive Immune responses: T Cells; Activation of adaptive Immune responses: B Cells; Immune Class Specification; Counter-regulation of Adaptive Immune Responses; Regulation of Innate Immunity by the Adaptive Immune System; Regulation of Innate Immune Cell Function; Counter-Regulation of Innate Immune Responses
Neutrophil Propagation of Inflammation: Production of Inflammatory MediatorsArachidonic Acid Metabolites; Cytokine Production; References; Suggested Readings; 4B Neutrophils II; Introduction; Neutrophil Differentiation, Maturation, and Other Generalities; Neutrophil Microbicidal Mechanisms; Neutrophil Receptors; The Role of Neutrophils in Acute Inflammation; Neutrophil-Derived Cytokines; Neutrophil Cross Talk With Other Cell Types: Role of Neutrophil-Derived Chemokines; Neutrophil Apoptosis; Neutrophils in Human Diseases; Conclusions; Suggested Readings
Suggested readings2 Resolution of Acute Inflammation and Wound Healing; Summary; Inflammation in Health and Disease; What is Inflammatory Resolution?; Soluble Mediators of Inflammation and Resolution; Controlling Onset; Onset to Resolution; Resolving Inflammation; Getting Rid of Leukocytes; Macrophages and Resolution -- Cellular Players and Homeostasis; Resolution of Adaptive Immune Responses; Wound Healing; Conclusion; Glossary of Terms; References; Suggested Readings; 3 Links between Innate and Adaptive Immunity; The innate and adaptive immune systems: definitions, context, and contrasts
Tissue-Specific Immunity: Organ-Specific Regulation of Immune ResponsesSuggested Readings; Part II. Individual Cell Types; 4A Neutrophils I; Introduction; Neutrophil Homeostasis: Myelopoiesis and Destruction; Neutrophil Anatomy: Morphology and Granules; Neutrophil Physiology: Activation and Function; Stimuli and Receptors; Intracellular Signaling and Second Messengers; Second Messengers; Kinases and Kinase Cascades; The Consequences of Neutrophil Activation: Adhesion, Migration, and Bacterial Killing; Neutrophil Adhesion and Migration; Phagocytosis and Bacterial Killing
Summary Provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion
Notes 5 Mast Cells as Sentinels of Inflammation
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cellular immunity.
Inflammation -- Immunological aspects.
Inflammation -- immunology.
Immunity, Cellular -- physiology.
Form Electronic book
Author Ayoub, Samir S.
Gilroy, Derek W.
Ward, Peter A.
ISBN 0511725027
1139195735 (electronic bk.)
9781139195737 (electronic bk.)
(hardback ; alk. paper)