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Book Cover
Streaming video
Author Bier, Ethan, speaker

Title Cross-genomic analysis of human disease genes / Ethan Bier
Published London : Henry Stewart Talks, 2008
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (65 min.) : color, sound)
Series The legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function', 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function'
Contents Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Drosophila -- genetics.
Genre/Form Video recordings.
Form Streaming video