Overview: Transporters as Targets for Drug Discovery -- Membrane Transporters: Structure, Function and Targets for Drug Design -- Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs -- Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter -- The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors -- Molecular Imaging of Transporters with Positron Emission Tomography -- Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c? -- Glycine Transporters and Their Inhibitors
Summary
Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. This title reviews advances in the field of transporters as targets for drug discovery over the years. It is suitable for scientists engaged in drug research in the pharmaceutical industry, biotech and academia
