| Description |
1 online resource (3044 p.) |
| Contents |
Title Page -- Copyright Page -- Section 1 Biological Basis of Childhood Cancer -- 1 Epidemiology of Childhood Cancer -- Cancer Surveillance and Descriptive Epidemiology -- Analytic Epidemiology -- Summary and Future Considerations -- 2 Heredity and Childhood Cancer -- Constitutional Chromosomal Abnormalities -- Structural Chromosomal Abnormalities -- Overgrowth Disorders and Imprinting Errors -- Autosomal Dominant Disorders -- Autosomal Recessive Disorders -- Issue in Genetic Testing for the Pediatric Oncology Patient -- 3 Molecular and Genetic Basis of Childhood Cancer |
|
General Nature of Cancer-Associated Genetic Aberrations -- Comprehensive Analysis of the Cancer Genome -- Germline Mutations -- Somatically Acquired Chromosomal Aberrations and Mutation -- Gross Chromosomal Rearrangements -- Oncogenic Consequences of Gross Chromosomal Rearrangements-General Themes -- Chromosomal Translocations Lead to Activation of Proto-Oncogenes and Generation of Oncogenic Fusion Genes -- Chromosomal Deletion Leads to Inactivation of Tumor Suppressor Genes -- Gene Amplification -- Point Mutations Leading to Gene Activation or Inactivation |
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Comprehensive Genomic Studies of Pediatric Tumors -- Mechanisms of Malignant Cell Transformation, Growth, and Clonal Expansion -- Outlook for Molecularly Targeted Therapies -- Summary -- 4 Biology of Childhood Cancer -- Gene Regulation -- Protein Regulation -- Signal Transduction -- Cell Proliferation -- Programmed Cell Death -- Cancer Metabolism -- Metastasis and the Tumor Microenvironment -- 5 Tumor Immunology of Childhood Cancer -- Overview of the Immune System -- Modern Concepts of Immune Surveillance -- T-Cell Recognition of Cancer -- Innate Immune Cells and the Tumor Microenvironment |
|
Immune Function in Cancer Patients -- Immunotherapy of Cancer -- Summary and Future Directions -- Section 2 Diagnosis and Evaluation of the Child with Cancer -- 6 Clinical Assessment and Differential Diagnosis of Suspected Childhood Cancer -- Children at Risk -- Time to Diagnosis -- Differential Diagnosis -- Establishing the Diagnosis -- Summary -- 7 Pathology and Molecular Diagnosis of Leukemias and Lymphomas -- Introduction -- Ancillary Studies -- Lymphoblastic Leukemia -- Myeloid Neoplasms -- Mature Lymphoid Neoplasms -- Histiocytic Disorders |
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8 Diagnostic Pathology of Pediatric Solid and Central Nervous System Malignancies -- Introduction -- Brief Pathologic Classification of Pediatric Solid Tumors -- Traditional Approaches to Childhood Solid Tumor Diagnosis -- Molecular Genetic Evaluation of Childhood Cancer -- Integrated Diagnostic Molecular Pathology of Pediatric Solid Tumors -- The Holistic Cancer Genome -- DNA -- RNA -- Emerging Technologies for Diagnosis -- The Future of Pediatric Cancer Diagnosis -- 9 Imaging Studies in the Diagnosis of Childhood Cancer -- Relative Merits of Available Imaging Procedures |
| Notes |
Description based upon print version of record |
|
General Concepts of Pediatric Tumor Imaging |
| Subject |
Tumors in children.
|
|
Tumors in children
|
| Form |
Electronic book
|
| Author |
Helman, Lee J
|
|
Adamson, Peter C
|
| ISBN |
9781975124816 |
|
1975124812 |
|
