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Title Biomarkers in clinical drug development / edited by John C. Bloom and Robert A. Dean
Published New York : Marcel Dekker, [2003]
Online access available from:
ProQuest Ebook Central (owned titles)    View Resource Record  


Description 1 online resource (viii, 295 pages) : illustrations
Series Drugs and the pharmaceutical sciences ; v. 132
Drugs and the pharmaceutical sciences ; v. 132
Contents Preface; Contents; Contributors; Biomarkers in Clinical Drug Development: Definitions and Disciplines; The Clinical Laboratory and Collection of Biomarker Data; Using Imaging Biomarkers to Demonstrate Efficacy in Clinical Trials: Trends and Challenges; Markers for Cardiac Repolarization and Risk Assessment; Development and Application of Interspecies Biomarkers in Nonclinical Safety Evaluations; Validation of Assays for the Bioanalysis of Novel Biomarkers: Practical Recommendations for Clinical Investigation of New Drug Entities; Validation of Biomarkers as Surrogates for Clinical Endpoints
Summary Presenting recent applications in clinical development, pharmacokinetic/ pharmacodynamic modeling, and clinical trial simulation, this in-depth reference studies the role of biomarkers in successful drug formulation and development--utilizing the latest discoveries in biomarker science to determine the safety and efficacy of emerging drug compounds
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Biochemical markers.
Clinical pharmacology.
Drugs -- Testing.
Pharmaceutical technology.
Drug Design.
Drug Evaluation -- methods.
Technology, Pharmaceutical.
Form Electronic book
Author Bloom, John C.
Dean, Robert Allen.
ISBN 0203911237
0824755197 (electronic bk.)
9780824755195 (electronic bk.)