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Title Osteoclasts : morphology, functions and clinical implications / Alexander J. Brown and Johanna S. Walker, editors
Published [Hauppauge], New York : Nova Biomedical, Nova Science Publishers, Incorporated, [2012]

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Description 1 online resource
Series Cell Biology Research Progress
Cell biology research progress.
Contents OSTEOCLASTS ; OSTEOCLASTS ; Contents; Preface; Modulation of Osteoclast Differentiation and Function in Rheumatoid Arthritis; Introduction; Osteoclasts in Rheumatoid Arthritis; Growth Factors; Macrophage Colony Stimulating Factor; Granulocyte Macrophage- Colony Stimulating Factor; Transforming Growth Factor-Beta; Tumor Necrosis Factor Super Family; Receptor Activator of NF-Kappa B Ligand; Tumor Necrosis Factor-Alpha; Osteoprotegerin; Interferon Family; Interleukin Family; Interleukin 1; Interleukin 6; Interleukin 10; Conclusion; Refrences
Osteoclast Formation and Function and Its role in Skeletal Bone DiseaseAbstract; Introduction; Multinucleation; Sealing Zone; Ruffled Border; Basolateral Membrane; OCs and Clinical Implications; Osteopetrosis; Pycnodysostosis; Paget's Disease; Osteoporosis; Cancer; Inflammatory Arthritis; Conclusion; Acknowledgments; References; The High Osteoclastogenic Potential of Human Osteosarcoma Cells: Reciprocal Interaction between MG63 Osteoblast-Like Cells and Osteoclast Precursors; Abstract; 1. Introduction; 2. Cell Culture Models; 2.1. MG63 Cell Line
2.2. Peripheral Blood Mononuclear Cells (PBMC)3. Osteoclastogenic Potential of the MG63; Cell Line; 3.1. Paracrine-Mediated Mechanisms; 3.2. Cell-to-Cell Contact Mechanisms; 4. Modulation of the MG63 Cell Behavior by Osteoclastic Cells; Conclusion; References; Osteoclast Biology in Paget's Disease of Bone; Abstract; Osteoclast Phenotype in PDB; Viral and Genetic Factors in Paget's Disease of Bone; Role of p62 in Osteoclast Signaling; p62 as a Shuttling Factor; Role of p62 Mutations in Paget's Disease of Bone; Conclusion; References; Osteoclasts: The Major Actors in Bone Resorption
AbstractIntroduction; Osteoclast Differentiation and Activation; Osteoclasts and Immune System Talk; Osteoclasts in Bone Metastases; Osteoclasts in Rheumatoid Arthritis; Osteoclasts in Periprosthetic Osteolysis; Osteoclasts in Pedriatic Disease; Osteoclasts in Osteoporosis; Conclusion; References; Role of the Immuno-Skeletal Interface in Physiological and Pathological Osteoclast Regulation; Abstract; Introduction; 1. Physiological Osteoclast Formation and the Role of the RANK/RANKL/OPG Axis; 2. Role of the Immuno-skeletal Interface in Physiological Osteoclast Renewal
A) T Cells and B Cells, the Centerpiece of Cell-mediated Immunityb) T Cells and B Cells, Critical Regulators of Basal Osteoclastogenesis; c) Disruption of the Immuno-skeletal Interface and Bone Loss Associated with HIV-Infection; d) The immuno-skeletal Interface and Osteoclastic Bone Loss Associated with inflammatory Disease; e) Role of the Immuno-skeletal interface in Estrogen Deficiency-induced Bone Loss; Conclusion; Acknowledgments; References; Multiple Functions of Osteoclasts and Potential Usefulness of Phosphatidylserine-Containing Liposomes on Bone Diseases; Abstract; Introduction
Bibliography Includes bibliographical references and index
Notes English
Description based on print version record
Subject Osteoclasts.
Bone resorption.
Bones -- Diseases.
HEALTH & FITNESS -- Diseases -- Musculoskeletal.
MEDICAL -- Orthopedics.
MEDICAL -- Rheumatology.
Bone resorption
Bones -- Diseases
Osteoclasts
Form Electronic book
Author Brown, Alexander J., editor
Walker, Johanna S., editor
LC no. 2020687904
ISBN 9781620813409
1620813408