| Description |
1 online resource |
| Contents |
Introduction to Cancer Stem Cells / Chengzhuo Gao, Robert E. Hollingsworth and Elaine M. Hurt -- DNA Repair Pathways and Mechanisms / Thomas S. Dexheimer -- Resistance and DNA Repair Mechanisms of Cancer Stem Cells: Potential Molecular Targets for Therapy / Aamir Ahmad, Yiwei Li, Bin Bao and Fazlul H. Sarkar -- DNA Repair in Normal Stem Cells / Olga Momčilović and Gerald Schatten -- DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells / Monica Venere, Jeremy N. Rich and Shideng Bao -- DNA Repair Mechanisms in Breast Cancer Stem Cells / Hong Yin and Jonathan Glass -- DNA Repair Mechanisms in Other Cancer Stem Cell Models / Mihoko Kai -- Pancreatic Cancer Stem Cells in Tumor Progression, Metastasis, Epithelial-Mesenchymal Transition and DNA Repair / Nagaraj S. Nagathihalli and Erika T. Brown -- Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for New Therapeutics / Lesley A |
| Summary |
The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types |
| Analysis |
Medicine |
|
Oncology |
|
Stem cells |
|
Biomedicine |
|
Molecular Medicine |
|
Cancer Research |
| Bibliography |
Includes bibliographical references |
| Subject |
Cancer cells.
|
|
DNA repair.
|
|
Stem cells.
|
|
Carcinogenesis -- Molecular aspects.
|
|
Neoplastic Stem Cells -- physiology
|
|
DNA Repair -- physiology
|
|
Neoplasms -- therapy
|
|
DNA Repair
|
|
Stem Cells
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
MEDICAL -- Oncology.
|
|
Cancer cells
|
|
Carcinogenesis -- Molecular aspects
|
|
DNA repair
|
|
Stem cells
|
| Form |
Electronic book
|
| Author |
Mathews, Lesley A
|
|
Cabarcas, Stephanie M
|
|
Hurt, Elaine M
|
| ISBN |
9789400745902 |
|
9400745907 |
|
9400745893 |
|
9789400745896 |
|
