| Description |
1 online resource (xvii, 270 pages, 16 unnumbered pages of plates) : illustrations (chiefly color) |
| Contents |
Machine generated contents note: 1.Resident Stem Cells in Kidney Tissue / Adalberto Vieyra -- Introductory Remarks -- Brief Description of the Structural Organization of the Mammalian Adult Kidney -- Stem Cells in Kidney Organogenesis -- Kidney Stem/Progenitor Cells: Niches and Isolation -- The Role of Stem/Progenitor Cells in Kidney Regeneration -- Role of Kidney Resident Stem/Progenitor Cells in the -- Establishment and Progression of Renal Disorders -- Glomerularsclerosis -- Tubular Lesions -- Progenitor/Resident Stem Cells and Renal Cancer -- Stem/Progenitor Cells in Kidney: Features for Therapeutic -- Use after the Few Trials with Bone Marrow Cells? -- References -- 2.Pancreatic Stem Cells / Mari C. Sogayar -- Introduction -- Embryogenesis and Organogenesis -- References -- 3.Tissue Engineering and the Role of Biomaterial Scaffolds / Karen L. Christman -- Introduction to Tissue Engineering -- Role of Biomaterials in Tissue Engineering |
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Clinical Translation and Commercialization -- Future of Tissue Engineering -- Cardiac Tissue Engineering -- Future of Cardiac Tissue Engineering -- References -- 4.Resident Neural Stem Cells / Rosalia Mendez-Otero -- Neurogenesis in the Adult Brain -- Neurogenesis during Development -- Neural Stem Cells -- The Subventricular Zone -- Subgranular Zone -- Neural Stem Cell Markers -- Neurogenesis's Regulators -- Cell Therapy -- References -- 5.Resident Stem Cell in Skin / Radovan Borojevic -- Introduction -- Interfollicular Epidermis -- Hair Follicle and Associated Structures -- Melanocytes -- Dermis -- Cell Therapies and Clinical Application of Skin Stem Cells -- References -- 6.Lung Resident Stem Cells / Patricia Rieken Macedo Rocco -- Lung Structure -- Hierarchy of Lung Resident Stem Cells -- Resident Epithelial Progenitor Cells -- Resident Endothelium Progenitor Cells -- Resident Mesenchymal Progenitor Cells -- Lung Resident Stem Cells in Respiratory Diseases |
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Main Challenges for the Identification of Lung Resident Stem Cells -- References -- 7.Skeletal Resident Stem Cells / Russell S. Taichman -- Bone Tissue Bone Marrow as a Source of Mesenchymal Stem -- Cells-Stem Cells for Bones -- Mesenchymal Cells in Orthopedic Bioengineering and Bone Repair -- Skeletal Stem Cells and the Vascular System -- Combined Action: Therapeutic Use of Mesenchymal Progenitors and Angiogenic Progenitors -- Cell Therapy in Pseudarthrosis -- Cell Therapy in Avascular Necrosis of the Femoral Head -- (Osteonecrosis) -- Acknowledgments -- References -- 8.Cardiac Stem Cells / Antonio Carlos Campos de Carvalho -- c-Kit Positive Cells -- Cardiosphere-Derived Cells -- Side Population -- Islet-1 Positive Cells -- Conclusions and Future Directions -- References -- 9.The Neural Crest and the Stem Cells of Neural Crest / Giordano Wosgrau Calloni -- Introduction -- The Neural Crest -- Neural Crest-Derived Stem Cells (NCSCs) |
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Are NC Cells a Source of Mesenchymal Stem Cells (MSCs)? -- Concluding Remarks -- Acknowledgments -- References -- 10.Liver Resident Stem Cell / Regina Coeli dos Santos Goldenberg -- Introduction -- Liver Development -- Liver Regeneration: The Hierarchy for Cell Response -- Stem/Progenitor Cells: The Second Front in Liver Regeneration -- Fetal Hepatic Stem Cell Niche -- Adult Liver Stem/Progenitor Cell Niche -- Liver Stem/Progenitors Cells and Cell Therapy -- References -- 11.Telocytes and Stem Cells / M.I. Nicolescu -- What Are Telocytes? -- What Defines Telocytes as a Unique, Distinct Cell Type? -- Comparison with Fibroblasts -- Where Are Telocytes Located? -- Telocyte Intercellular Relationships -- Phenotype "Portrait" -- The Tandem Telocytes & Stem Cells -- A Hope for Regenerative Medicine -- Future Research Directions -- References -- 12.Pericytes as the Source of Mesenchymal Stem Cells / Nance Beyer Nardi -- Pericytes -- Relationship between Pericytes and MSCs |
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The Plasticity Issue -- Pericytes as Stem Cells in the Body -- Conclusion -- Acknowledgments -- References |
| Summary |
In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. . Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration. . Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research . Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Information from publisher's Web site; (ScienceDirect; viewed on Sept. 18, 2012) |
| Subject |
Stem cells.
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Hematopoietic stem cells.
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Stem cells -- Therapeutic use
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Regenerative medicine.
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Mesenchymal stem cells.
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Adult Stem Cells
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Mesenchymal Stem Cells
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Regenerative Medicine -- methods
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Cell- and Tissue-Based Therapy -- methods
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Stem Cells
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Hematopoietic Stem Cells
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Regenerative Medicine
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MEDICAL -- Research.
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Mesenchymal stem cells
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Hematopoietic stem cells
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Regenerative medicine
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Stem cells
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| Form |
Electronic book
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| Author |
Goldenberg, Regina Coeli dos Santos.
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Carvalho, Antonio Carlos Campos de.
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| ISBN |
9780124160125 |
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0124160123 |
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0123914418 |
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9780123914415 |
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9781283619813 |
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1283619814 |
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9786613932266 |
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6613932264 |
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