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Author Chemicals, Panel on Anticholinesterase

Title Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents
Published Washington : National Academies Press, 1981
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Description 1 online resource (298 pages)
Contents ""POSSIBLE LONG-TERM HEALTH EFFECTS OF SHORT-TERM EXPOSURE TO CHEMICAL AGENTS""; ""Copyright""; ""ACKNOWLEDGEMENTS""; ""PREFACE""; ""EXECUTIVE SUMMARY""; ""ANTICHOLINESTERASE CHEMICALS""; ""ANTICHOLINERGIC CHEMICALS""; ""MORTALITY""; ""MORBIDITY""; ""Contents""; ""1 INTRODUCTION""; ""HISTORY OF THE EDGEWOOD TESTING PROGRAM""; ""PROCEDURES USED AT THE EDGEWOOD CHEMICAL TESTING PROGARM""; ""RECRUITMENT OF VOLUNTEERS""; ""GUIDELINES FOLLOWED IN THE PROTECTION OF SUBJECTS""; ""INVESTIGATORS""; ""SELECTION OF DOSES FOR HUMAN TESTS""; ""RANGE OF DOSES""; ""SAFETY MARGIN""; ""2 ANTICHOLINESTERASES""
""CENTRAL EFFECTS""""POISONING BY BELLADONNA ALKALOIDS""; ""SYMPTOMS AND SIGNS OF ATROPINE POISONING""; ""TREATMENT""; ""MECHANISM OF ACTION""; ""ABSORPTION, FATE, AND EXCRETION""; ""PHARMACOLOGICAL PROPERTIES OF SYNTHETIC ATROPINE DERIVATIVES""; ""ROLE OF DRUG DISPOSITION IN EXPLAINING DIFFERENCES AMONG ANTICHOLINERGIC COMPOUNDS""; ""ATROPINE""; ""BZ""; ""ANIMAL TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS""; ""IMMEDIATE EFFECTS""; ""EA 3443""; ""EA 3834""; ""LONG-TERM AND DELAYED EFFECTS""; ""Atropine""; ""Clidinium (Quartzan)""; ""Other Data""; ""HUMAN TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS""
""CHEMISTRY OF ANTICHOLINESTERASES""""“REVERSIBLE� INHIBITORS""; ""ORGANOPHOSPHORUS (OP) INHIBITORS""; ""ABSORPTION, FATE, AND EXCRETION OF ANTI-CHES""; ""MECHANISMS OF ACTION""; ""INHIBITION OF ACETYLCHOLINESTERASE BY ANTICHOLINESTERASES""; ""REACTIVATION OF ACHE""; ""AGING OF INHIBITED ACHE""; ""CHOLINERGIC RECEPTOR AND ACH CHANNEL""; ""PRESYNAPTIC ACTION""; ""NERVE MEMBRANE""; ""CENTRAL NERVOUS SYSTEM""; ""“NEUROTOXIC� ESTERASE (NTE)""; ""BIOCHEMICAL AND METABOLIC CHANGES""; ""OP ALKYLATION""; ""BIOLOGIC AND CLINICAL EFFECTS""; ""ACUTE EFFECTS: PHARMACOLOGY""; ""Eye""
""Gastrointestinal Tract""""Actions at Other Autonomic Sites""; ""Neuromuscular Junction""; ""Brain""; ""ACUTE TOXIC EFFECTS""; ""DELAYED NEUROPATHY (CNS-PNS DISTAL AXONOPATHY)""; ""Clinical Features""; ""Neuropathologic Features""; ""Neuropathic Potency""; ""LONG-TERM BRAIN DYSFUNCTION""; ""JUNCTIONAL NEUROMYOPATHY""; ""OTHER ADVERSE HEALTH EFFECTS""; ""Mutagenicity""; ""Carcinogenicity""; ""Fetal and Teratogenic Effects""; ""Effects on Male Reproduction""; ""Cataractogenic Effects""; ""Hemocoagulation""
""IMMEDIATE AND DELAYED EFFECTS IN VOLUNTEERS AFTER SINGLE OR REPEATED EXPOSURE TO ANTI-CHES AT EDGEWOOD""""MORTALITY DATA""; ""EVALUATION OF THE LIKELIHOOD OF LONG-TERM ADVERSE HEALTH EFFECTS""; ""BRAIN DYSFUNCTION""; ""JUNCTIONAL NEUROMYOPATHY AND DELAYED NEUROPATHY""; ""OTHER ADVERSE HEALTH EFFECTS""; ""Mutagenicity, Carcinogenicity, and Male Reproductive Effects""; ""Cataractogenicity""; ""Blood Changes""; ""CONCLUSIONS""; ""REFERENCES""; ""3 ANTICHOLINERGICS""; ""ATROPINE, SCOPOLAMINE, AND RELATED THERAPEUTIC ANTICHOLINERGIC CHEMICALS""; ""SITES OF ACTION""; ""PERIPHERAL EFFECTS""
Notes ""Dosing considerations""
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Form Electronic book
Author Chemicals, Panel on Anticholinergic
Toxicology, Committee on
ISBN 0309593786
9780309593786