| Description |
1 online resource (597 pages) |
| Contents |
Intro -- Preface -- Contents -- Contributors -- 1: Surgical Treatment of Colorectal Cancer Liver Metastases (CRLM) -- Historical Aspects -- References -- 2: The Biology of Colorectal Liver Metastases -- Introduction -- Colorectal Carcinogenesis -- Colon Cancer Stem Cells and the Hierarchical Organization Model -- CRC Molecular Classification Subtypes and the Role of Stroma -- Endothelial Cells and Angiogenesis -- Epithelial-Mesenchymal Transition (EMT) and Colorectal Cancer (CRC): Extravasation -- Circulating Tumor Cells (CTCs) -- Extravasation and Metastatic Dormancy -- Immune System |
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Conclusion -- References -- 3: Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases -- Introduction -- KRAS -- BRAF -- TP53 -- PIK3CA -- APC -- SMAD4 -- Microsatellite Instability -- Circulating Tumor Cells -- Conclusion -- References -- 4: Diagnosis of Colorectal Liver Metastases -- Definition -- Follow-Up After Treatment of the Primary Tumor -- Clinical Diagnosis -- Laboratory Diagnosis -- Biological Diagnosis -- Imaging Diagnosis -- Methods -- Ultrasonography -- Contrasted Ultrasonography -- Computed Tomography -- Positron Emission Computed Tomography (PET-CT) |
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Magnetic Resonance Imaging -- Magnetic Resonance with Specific Hepatobiliary Contrast -- Intraoperative Ultrasound -- Typical Presentation of Hepatic Colorectal Metastases -- Particular Situations -- Small Hepatic Lesions -- Neoadjuvant Chemotherapy Imaging Workup -- Final Recommendation -- References -- 5: Role of Imaging in the Management of Patients with Potentially Resectable CRLM -- Introduction -- Role of Imaging in Detection of CRLM -- Ultrasound -- Computed Tomography (CT) -- Magnetic Resonance Imaging (MRI) -- Positron Emission Tomography (PET) |
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Role of Imaging in Surgical Planning for CRLM -- Vascular Assessment -- Liver Volumetry -- Conclusion -- References -- 6: Staging Classifications of Colorectal Liver Metastases -- Introduction -- Prognostic Factors for CRLM Patients Undergoing Liver Resection -- Staging System for CRLM -- TNM Cancer Staging System for Colon and Rectum Cancer -- Japanese Staging System for CRLM -- Risk Scoring Systems for CRLM Patients Undergoing Liver Resection -- Validation Study of Risk Scoring Systems for CRLM Patients Treated with Liver Resection -- New Aspects of the Prognostic Score System |
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Nomogram to Predict Prognosis of Resected CRLM -- Conclusion -- References -- 7: Prognostic Factors of Colorectal Cancer Liver Metastasis -- Introduction -- Factors Related to the Patient -- Factors Related to Primary Tumor -- Factors Related to Liver Tumor -- Conclusion -- References -- 8: Clinical Scoring Systems for Colorectal Cancer Liver Metastases -- Introduction -- Early Scoring Systems -- Contemporary Scoring Systems -- Validation and Comparison of Existing Scoring Systems -- Should I Use a Scoring System? If So, Which One? When Should I Use a Scoring System? -- Conclusion -- References |
| Summary |
Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases |
| Notes |
9: What Is the Impact of Positive Margins in the Liver? |
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Includes index |
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Print version record |
| Subject |
Liver -- Cancer.
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Colon (Anatomy) -- Cancer.
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Rectum -- Cancer.
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Liver Neoplasms
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Colon (Anatomy) -- Cancer
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Liver -- Cancer
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Rectum -- Cancer
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| Form |
Electronic book
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| Author |
Correia, Mauro Monteiro
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Choti, Michael A
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Rocha, Flavio G.
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Wakabayashi, Go.
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| ISBN |
9783030254865 |
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3030254860 |
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3030254852 |
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9783030254858 |
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9783030254872 |
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3030254879 |
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9783030254889 |
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3030254887 |
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