| Description |
1 online resource (xiii, 416 pages) : color illustrations |
| Series |
Epigenetics and Human Health, 2191-2262 |
|
Epigenetics and human health, 2191-2262
|
| Contents |
Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function |
| Summary |
In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders |
| Analysis |
biomedische wetenschappen |
|
biomedicine |
|
neoplasms |
|
humane genetica |
|
human genetics |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Notes |
Includes index |
| Bibliography |
ReferencesChapter 3: Epigenetic and Transcriptional Mechanisms Regulating Blood Cell Development in Zebrafish; 3.1 Introduction; 3.2 Overview of Zebrafish Hematopoiesis; 3.3 Genetic and Epigenetic Regulation of Zebrafish Hematopoiesis; 3.3.1 Transcriptional Control of the Emergence of Hematopoietic Cells in Early Embryos; 3.3.2 Regulation of Definitive HSC Formation; 3.3.3 Regulation of Lineage Specification; 3.3.4 Epigenetic Regulators in Zebrafish Hematopoiesis; 3.4 Blood Disease Modeling Using Zebrafish; 3.5 Conclusions and Future Perspectives; References |
| Notes |
English |
|
Online resource; title from PDF title page (SpringerLink, viewed March 17, 2014) |
| In |
Springer eBooks |
| Subject |
Epigenetics.
|
|
Blood cells.
|
|
Blood -- Diseases.
|
|
Epigenomics
|
|
Blood Cells
|
|
Hematologic Diseases
|
|
SCIENCE -- Life Sciences -- Anatomy & Physiology.
|
|
Blood cells
|
|
Blood -- Diseases
|
|
Epigenetics
|
| Form |
Electronic book
|
| Author |
Bonifer, Constanze, editor
|
|
Cockerill, Peter N., editor
|
| ISBN |
9783642451980 |
|
3642451985 |
|
3642451977 |
|
9783642451973 |
|
9783642451997 |
|
3642451993 |
|
9783662514665 |
|
3662514664 |
|
