| Description |
1 online resource (450 p.) |
| Contents |
Intro -- Foreword -- Contents -- 1: The Method Sets the Tone -- 1.1 Introduction -- 1.2 The Heroes -- 1.3 The Endless Revolution -- 1.3.1 The Hypothesis -- 1.3.2 The Design -- 1.3.3 Evidence-Based Dentistry -- 1.4 Conclusion -- References -- Evidence-Based Dentistry Related References -- 2: Preclinical Studies Design and Place of Rodents -- 2.1 Experimental Animal Model -- 2.1.1 Animal Species: Naturally-Occurring, Purpose-Bread, and/or Genetically Modified -- 2.1.2 General Use in Medical Devices Research -- 2.1.3 Financial Considerations -- 2.2 Surgical Model |
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2.2.1 Surgical Anatomical Site and Surgical Procedures for Implant Dentistry -- 2.2.1.1 Surgical Locations -- Extraoral -- Anatomy and Histology -- Function and Physiology (Movement, Loading) -- Advantages/Inconveniences in Implant Dentistry -- Recommendations -- Intraoral -- Anatomy and Histology -- Function and Physiology (Movement, Loading, and Occlusion) -- Advantages/Inconveniences in Implant Dentistry Anatomy and Histology -- Recommendations -- 2.2.1.2 Surgical Procedures -- Extraoral: Description of the Procedures |
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Animal Welfare, Preparation for Survival Surgery, and Anesthesia (General, Local) -- Surgical Step by Step: Anterior-Distal Surface of Femur Metaphysis -- Surgical Step-by-Step:Femoral Condyle -- Surgical Step by Step: Medial-Proximal Surface of Tibia Metaphysis -- Follow-up and Termination -- Recommendations -- Intraoral: Description of the Procedures -- Animal Welfare, Preparation for Survival Surgery and Anesthesia (General, Local) -- Surgical Step-by-Step: Rat -- Surgical Step-by-Step: Mouse -- Follow-Up and Termination -- Recommendations -- 2.3 Investigative Methods of Evaluation |
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2.3.1 X-Rays -- 2.3.2 Micro-CT -- 2.3.3 Histology (Remove Implant or Not) -- 2.3.4 Optics and Electronic Histology-Histomorphometry (Including Immunohistolabeling) -- 2.3.5 Biomechanics -- 2.3.5.1 Push-in Test -- 2.3.5.2 Pull-Out Test -- 2.3.6 Bacteriology -- 2.3.7 Genomics -- 2.4 Flag Ship Results from the Literature Using These Experimental-Surgical Models (Outlining Your Own Results): Critical Mini-Review -- 2.5 Expert Opinion: Balancing Models (Experimental and Surgical) Validation and Validity -- References -- 3: Preclinical Studies Design and Place of Rabbits |
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3.1 Experimental Animal Model -- 3.1.1 Animal Species: Naturally-Occurring, Purpose-Bred and/or Genetically Modified -- 3.1.1.1 Animal Welfare -- 3.1.1.2 Handling and Husbandry -- 3.1.1.3 Health Status -- 3.1.2 General Use in Medical Devices Research -- 3.1.3 Financial Considerations -- 3.2 Surgical Model: Surgical Anatomical Site and Surgical Procedures for Implant Dentistry -- 3.2.1 Surgical Locations, Anatomy, and Histology -- 3.2.1.1 General Anatomical Information -- 3.2.1.2 Extraoral -- Femur and Tibia -- Skull -- 3.2.1.3 Intra Oral -- Maxilla and Mandible -- Sinuses |
| Summary |
This book explores, in a comprehensive and systematic manner, Surgical Research methodologies to the design and development of investigational studies in the field of implant-based oral rehabilitation. Such studies are linked in a chain binding in vitro, in vivo, ex vivo, and digital evaluations. An ambitious objective consists in exposing how investigators can generate and deliver knowledge by capturing synergy coming from preclinical and clinical trials. Accordingly, throughout the book, translational aspects are closely scrutinized. The opening chapters consider materials, methods and procedures for preclinical and clinical studies in which approaches and models are extensively described. The focus then moves to the process by which application of histology, biomechanics, biomarkers, cellular/molecular biology, and imaging technologies lead to new results and consequently novel treatment concepts in implant dentistry, implant borne prosthetic rehabilitations and the replacement or regeneration of tissues. Finally, the exciting opportunities afforded by the digital world are addressed. This book shall be a valuable resource and time-saving tool for a wide audience of researchers, students, practitioners, and academics |
| Notes |
3.2.1.4 Function and Physiology (Movement, Loading) |
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Description based on online resource; title from digital title page (viewed on November 06, 2023) |
| Subject |
Dental implants.
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Dental Implants
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Dental implants.
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| Form |
Electronic book
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| Author |
Dard, Michel M., editor
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| ISBN |
3031372344 |
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9783031372346 |
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