| Description |
1 online resource (269 pages) |
| Series |
Advances in protein chemistry and structural biology ; v. 90 |
|
Advances in protein chemistry and structural biology ; v. 90.
|
| Contents |
Front Cover; Organisation of Chromosomes; Copyright; Contents; Preface; Chapter One: Large Tandem Repeats Make up the Chromosome Bar Code: A Hypothesis; 1. Introduction; 2. Satellite DNA in the Mouse Genome; 2.1. Satellite DNA and tandem repeats; 2.2. Mouse genome as a model for the tandem repeat search; 2.3. Lack of tandem repeats in the reference genome; 2.4. Large tandem repeats in WGS assemblies; 2.5. Large tandem repeat graphic representation; 2.6. TEs-related tandem repeats; 2.7. Family TRPC-21A-MM; 3. Tandem Repeat Position Defined by Fish |
|
3.1. Chromosomes of bone marrow cells: first set of probes3.2. Chromosomes of embryonic fibroblasts: second set of probes; 3.3. Hybridization summary; 4. ̀̀Bar Code ́ ́ Hypothesis; 4.1. Internal large tandem repeats in human and mouse reference genomes; 4.2. Proteins specific in binding to tandem repeats; 4.3. RNA-mediated mechanism of tandem repeat association; 4.4. ̀̀Bar code ́ ́ as morphogenetic program; Acknowledgments; References; Chapter Two: Mammalian Satellite DNA: A Speaking Dumb; 1. Introduction; 2. Heterochromatin Criteria; 3. The Constitutive HC DNA; 3.1. Satellite DNA |
|
3.2. Non-satellite centromeric and pericentromeric DNA4. Transcription of HC DNA; 4.1. Early data on constitutive HC DNA decondensation and transcription; 4.2. Transcription of constitutive HC DNA in mammals; 4.2.1. Heterochromatic genes; 4.2.2. Satellite DNA transcripts; 4.2.3. Transcription in stress condition; 4.2.4. Transcription in development; 4.2.5. Cell-cycle-regulated transcription of pericentromeric satellites; 4.2.6. Transcription in senescent cells; 4.2.7. Satellite DNA transcription during carcinogenesis; 4.2.8. Regulatory mechanisms of satellite DNA transcription |
|
5. Functions of Centromeric and Pericentromeric HC DNA Transcription6. Conclusions; Acknowledgments; References; Chapter Three: Zinc Finger Proteins and the 3D Organization of Chromosomes; 1. The 3D Organization of the Genome and Loops; 2. CTCF and its Role in the 3D Genome Organization; 3. A Model for CTCF; 3.1. CTCF as an unstructured protein with flexible linkers; 3.2. Conformational properties of CTCF; 4. A Model for CTCF Binding; 4.1. Formulation of the model; 4.2. Flexible linkers and domains; 4.3. Rules for multidomain binding |
|
4.4. States of the system with flexible linkers and domains4.5. The effect of flexible linkers on the binding affinity; 4.6. Enhancement of binding affinity of zinc finger proteins by flexible linkers; 4.7. Effect of flexible linkers on the structure of binding maps of zinc finger proteins; 5. A Method to Compute Similarity for Unstructured Proteins; 5.1. Geometric similarity; 5.2. Geometry versus topology; 5.3. Using topology to compute similarity; 5.3.1. A barcode representation of topology; 5.3.2. A barcode-based topological similarity measure |
| Summary |
Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics |
| Notes |
Includes indexes |
| Subject |
Chromosomes.
|
|
Chromosomes
|
|
SCIENCE -- Life Sciences -- Molecular Biology.
|
|
Chromosomes
|
| Form |
Electronic book
|
| Author |
Donev, Rossen.
|
| ISBN |
9780124105447 |
|
0124105440 |
|
