| Description |
1 online resource (viii, 128 pages) : illustrations |
| Series |
Memoirs of the American Mathematical Society, 0065-9266 ; no. 1044 |
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Memoirs of the American Mathematical Society ; no. 1044.
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| Contents |
Contents -- Abstract -- Chapter 1. Introduction -- 1.1. Informal description of the limit model -- 1.2. Example I: Mutation counting -- 1.3. Example II: Polynomial selective costs -- 1.4. Example III: Demographic selective costs -- 1.5. Comments on the literature -- 1.6. Overview of the remainder of the work -- Chapter 2. Definition, Existence, and Uniqueness of the Dynamical System -- 2.1. Spaces of measures -- 2.2. Definition of the dynamical system -- 2.3. Existence and uniqueness of solutions -- 2.4. Lemmas used in the proof of existence and uniqueness -- Chapter 3. Equilibria -- 3.1. Introductory example: One-dimensional systems -- 3.2. Introductory example: Multiplicative selective costs -- 3.3. Frechet derivatives -- 3.4. Existence of equilibria via perturbation -- 3.5. Concave selective costs -- 3.6. Concave selective costs: Existence and stability of equilibria -- 3.7. Iterative computation of the minimal equilibrium -- 3.8. Stable equilibria in the concave setting via perturbation -- 3.9. Equilibria for demographic selective costs -- Chapter 4. Mutation, Selection, and Recombination in Discrete Time -- 4.1. Mutation and selection in discrete time -- 4.2. Recombination in discrete time -- 4.3. Recombination trees and annealed recombination -- 4.4. Vintages -- Chapter 5. Shattering and the Formulation of the Convergence Result -- 5.1. Shattering of random measures -- 5.2. Consequences of shattering -- 5.3. Convergence to Poisson of iterated recombination -- 5.4. Atoms in the initial intensity -- 5.5. Preview of the main convergence result -- Chapter 6. Convergence with Complete Poissonization -- Chapter 7. Supporting Lemmas for the Main Convergence Result -- 7.1. Estimates for Radon-Nikodym derivatives -- 7.2. Comparisons with complete Poissonization -- Chapter 8. Convergence of the Discrete Generation System -- 8.1. Outline of the proof -- 8.2. The convergence theorem -- Appendix A. Results Cited in the Text -- A.1. Gronwall's Inequality -- A.2. Two expectation approximations -- A.3. Identities for Poisson random measures -- A.4. Bounds for Poisson random measures -- A.5. Bounds for Radon-Nikodym derivatives -- Bibliography -- Index -- Glossary of Notation |
| Summary |
"We investigate a continuous time, probability measure-valued dynamical system that describes the process of mutation-selection balance in a context where the population is infinite, there may be infinitely many loci, and there are weak assumptions on selective costs. Our model arises when we incorporate very general recombination mechanisms into an earlier model of mutation and selection presented by Steinsaltz, Evans and Wachter in 2005 and take the relative strength of mutation and selection to be sufficiently small. The resulting dynamical system is dynamical system a flow of measures on the space of loci. Each such measure is the intensity measure of a Poisson random measure on the space of loci: intensity measure the points of a realization of the random measure record the set of loci at which the genotype of a uniformly chosen individual differs from a reference wild type due to an accumulation of ancestral mutations. Our motivation for working in such a general setting is to provide a basis for understanding mutation-driven changes in age-specific demographic schedules that arise from the complex interaction of many genes, and hence to develop a framework for understanding the evolution of aging. We establish the existence and uniqueness of the dynamical system, provide conditions for the existence and stability of equilibrium states, and prove that our continuous-time dynamical system is the limit of a sequence of discrete-time infinite population mutation-selection-recombination models in the standard asymptotic regime where selection and mutation are weak relative to recombination and both scale at the same infinitesimal rate in the limit." |
| Notes |
"March 2013, Volume 222, Number 1044 (third of 5 numbers)." |
| Bibliography |
Includes bibliographical references (pages 121-123) and index |
| Notes |
Print version record |
| Subject |
Evolutionary genetics.
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Mutation (Biology)
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Genetic recombination.
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SCIENCE -- Life Sciences -- Biochemistry.
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Evolutionary genetics
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Genetic recombination
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Mutation (Biology)
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| Form |
Electronic book
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| Author |
Steinsaltz, David, 1966- author.
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Wachter, Kenneth W., author
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| ISBN |
9780821895115 |
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0821895117 |
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