| Description |
1 online resource (xvi, 198 pages) : color illustrations |
| Contents |
Historical Review / Alessandra Fanciulli and Gregor K. Wenning -- Epidemiology / Florian Krismer and Gregor K. Wenning -- Neuropathology / Kurt Jellinger -- Aetiopathogenesis / Kurt Jellinger and Florian Krismer -- Animal Models / Nadia Stefanova -- Clinical Presentation / Alessandra Fanciulli and Gregor K. Wenning -- Clinical Diagnostic Criteria / Alessandra Fanciulli and Gregor K. Wenning -- Natural History / Alessandra Fanciulli and Gregor K. Wenning -- Investigations / Florian Krismer and Gregor K. Wenning -- Treatment |
| Summary |
This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C). The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson's disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders |
| Notes |
Includes index |
|
Online resource; title from PDF title page (SpringerLink, viewed September 26, 2013) |
| Subject |
Degeneration (Pathology)
|
|
Brain -- Degeneration.
|
|
Multiple System Atrophy
|
|
HEALTH & FITNESS -- Diseases -- General.
|
|
MEDICAL -- Clinical Medicine.
|
|
MEDICAL -- Diseases.
|
|
MEDICAL -- Evidence-Based Medicine.
|
|
MEDICAL -- Internal Medicine.
|
|
Médecine.
|
|
Brain -- Degeneration
|
|
Degeneration (Pathology)
|
| Form |
Electronic book
|
| Author |
Wenning, Gregor K., editor author
|
|
Fanciulli, Alessandra, editor author
|
| ISBN |
9783709106877 |
|
3709106877 |
|
