Description |
1 online resource (223 pages) : illustrations |
Series |
Current directions in autoimmunity, 1422-2132 ; vol. 2 |
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Current directions in autoimmunity ; v. 2.
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Contents |
Contents -- Oral Tolerance as a Treatment Modality for Autoimmune Diseases -- Anti- CD4 Monoclonal Antibody Therapy in Human Autoimmune Diseases -- Novel Concepts of Tumor Necrosis Factor Action in Autoimmune Pathology -- Anti- TNFa Therapy in Rheumatoid Arthritis Current and Future Directions -- Cytokine- Directed Targeting in Chronic Arthritis -- Interleukin- 10: Therapeutic Prospects in Rheumatoid Arthritis -- Immunomodulation of Crohn s Disease -- Retroviral and Lentiviral Gene Therapy for Autoimmune Disease -- Application of Gene Therapy in Autoimmune Disease |
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DNA Vaccination in the Treatment of Autoimmune DiseaseAuthor Index -- Subject Index |
Summary |
The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology |
Bibliography |
Includes bibliographical references and indexes |
Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
Subject |
Autoimmune diseases -- Genetic aspects
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Autoimmune diseases -- Treatment
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Autoimmunity.
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Biological response modifiers -- Therapeutic use
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Gene therapy.
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Immunogenetics.
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Gene therapy -- Methodology
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Autoimmune diseases -- Therapeutic use
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Autoimmune Diseases -- therapy
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Autoimmunity
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Genetic Therapy
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Immunogenetics
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Biological Therapy -- methods
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Genetic Therapy -- methods
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Autoimmune diseases -- Genetic aspects
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Autoimmune diseases -- Treatment
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Autoimmunity
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Biological response modifiers -- Therapeutic use
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Gene therapy
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Immunogenetics
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Maladies auto-immunes -- Thérapeutique.
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Biothérapie -- Méthodes.
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Thérapie génique -- Méthodes.
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Autoimmunité.
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Immunogénétique.
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Maladies autoimmunes -- Aspect génétique.
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Form |
Electronic book
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Author |
Fathman, C. Garrison
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ISBN |
9783318004908 |
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3318004901 |
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