| Description |
1 online resource (888 pages) |
| Series |
Lung Biology in Health and Disease |
|
Lung biology in health and disease.
|
| Contents |
Front cover; Introduction; Preface; Contributors; Contents; 1 Introduction to Lung Injury; I. Overview; II. Acute Lung Injury; III. Chronic Lung Injury; IV. Therapeutic Approaches for Diseases Involving Lung Injury; V. Summary of Coverage and Chapter Organization; References; 2 Principles of Lung Development, Growth, and Repair; I. Overview; II. Introduction; III. Lung Organogenesis; IV. Postnatal Development and Growth of the Lung; V. Postnatal Lung Disease and Injury; VI. Repair in the Postnatal Lung; VII. Summary; References; 3 Acute Lung Injury: Etiologies and Basic Features; I. Overview |
|
II. Introduction to Acute Lung InjuryIII. Overview of the Inflammatory Response; IV. Clinical ALI and ARDS; V. Summary; Acknowledgment; References; 4 Mediators and Inflammatory Cell Recruitment in Acute Lung Injury; I. Overview; II. Introduction; III. Innate Host Defense; IV. Early Response Cytokines; V. Inflammatory Cell Recruitment; VI. Chemotactic Cytokines (Chemokines); VII. Summary; Acknowledgments; References; 5 Chronic Lung Injury: Basic Features and Clinical Relevance; I. Overview; II. Introduction; III. Generalized Cellular Responses to Stress and Injury |
|
IV. Lung Injury and Its MechanismsV. Lung Defense Mechanisms; VI. Fibroproliferation and Chronic Lung Disease; VII. Summary; References; 6 Mediators and Mechanisms in Chronic Lung Injury and Fibrosis; I. Overview; II. Introduction; III. Relevance of Tumor Necrosis Factor Alpha for Pulmonary Fibrosis; IV. Platelet-Derived Growth Factor; V. Connective Tissue Growth Factor; VI. Transforming Growth Factor Beta; VII. Summary; Acknowledgments; References; 7 Roles of Reactive Oxygen and Nitrogen Species in Lung Injury; I. Overview; II. Introduction |
|
III. Chemistry and Biochemistry of Reactive Oxygen and Nitrogen SpeciesIV. Biological Effects of Reactive Oxygen and Nitrogen Species; V. Reactive Species in ALI and ARDS; VI. Summary; Acknowledgments; References; 8 Vascular Dysfunction in Lung Injury; I. Overview; II. Normal Growth and Development of the Pulmonary Vascular Bed; III. Regulation of Neonatal Vascular Tone; IV. Clinical Pulmunary Vascular Dysfunction; V. Animal Models; VI. Mechanisms of Vascular Dysfunction; VII. Therapies for Vascular Dysfunction; VIII. Summary; References; 9 Surfactant Activity and Dysfunction in Lung Injury |
|
I. OverviewII. Endogenous Surfactant and Its Activity; III. Deficiency and Dysfunction of Lung Surfactant; IV. Methods for Measuring Lung Surfactant Surface Activity and Dysfunction; V. Overview of Inhibitors and Mechanisms; VI. Surfactant Inactivation by Blood Proteins; VII. Surfactant Inactivation by Cell Membrane Lipids, Fluid Free Fatty Acids, and Lysophospholipids; VIII. Surfactant Dysfunction from Interactions with Reactive Oxygen or Nitrogen Species; IX. Surfactant Dysfunction Involving Large Aggregates; X. Additivity of Lung Surfactant Inhibitors |
| Summary |
Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and |
| Notes |
XI. Physiological Correlates of Lung Surfactant Dysfunction and Replacement in Animals |
|
Print version record |
| Subject |
Lungs -- Diseases -- Treatment
|
|
Lungs.
|
|
Pneumonia.
|
|
Lung
|
|
Pneumonia
|
|
Lungs
|
|
Lungs -- Diseases -- Treatment
|
|
Pneumonia
|
| Form |
Electronic book
|
| Author |
Finkelstein, Jacob
|
|
Holm, Bruce
|
| ISBN |
9781135522018 |
|
1135522014 |
|
