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E-book
Author Fioroni, Marco, author

Title [Beta]-barrel channel proteins as tools in nanotechnology : biology, basic science and advanced applications / Marco Fioroni, Tamara Dworeck, Francisco Rodriguez-Ropero
Published Dordrecht : Springer, 2014
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Description 1 online resource (xii, 168 pages) : illustrations (some color)
Series Advances in Experimental Medicine and Biology, 0065-2598 ; volume 794
Advances in experimental medicine and biology ; v. 794. 0065-2598
Contents Biology -- Biophysical Characterization -- Theoretical Considerations and Computational Tools -- Biotechnology -- Technological Applications -- Final Considerations
Summary B-barrel outer membrane channel proteins (OMP) have great potential as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties without affecting the overall protein structure and stability. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. The b-barrel structure serviceability for the nano-material design will be its chief topic giving a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel to be adapted to a non-biological synthetic (i.e. polymer) environment, rendering it competitive with artificial non-biological nano-pores will be outlined specifically the design of a set of protein nano-channels with tailored geometry (diameter, length), conductance and functionality will be reported as a case study. In order to make this book a valuable source of information for both biotechnologists and other scientists interested in bio-nanotechnology an overview of the different steps involved in the nano-channel protein design and production will be reported. The scientific strategy from concept design, theoretical considerations, genetic engineering and large scale production, to system assembly and biophysical characterization with an overview on technological applications including membrane/polymersome technology, will be described
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013)
Subject Membrane proteins.
Nanotechnology.
Bacterial Outer Membrane Proteins.
Porins.
Form Electronic book
Author Dworeck, Tamara, author
Rodriguez-Ropero, Francisco, author
ISBN 9789400774292 (electronic bk.)
940077429X (electronic bk.)