| Description |
1 online resource (ix, 412 pages) |
| Contents |
Overview of existing therapies / Jiannis Mountzios and Jean-Charles Soria -- Signal transduction inhibitors, HER family, EGFR inhibition, and clinical achievements / Giuseppe Giaccone and Paolo Zucali -- HER2 inhibition and clinical achievements / Toru Mukohara and Pasi A. Jänne -- Pan-HER inhibitors / Gérard Milano -- Inhibiting the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway / Janet E. Dancey -- Farnesyl transferase inhibitors in cancer: promise, but limited proof / Laura Fanucchi, Michael P. Fanucchi, and Fadlo R. Khuri -- Protein Kinase C inhibitors in the treatment of non-small cell lung cancer / Yun Oh [and others] -- Signal transduction inhibitors: PDGFR and c-KIT inhibitors / Jean-Yves Blay [and others] -- The insulin-like growth factor 1 receptor : a target for cancer treatment / Yungan Tao, Jean Bourhis, and Eric Deutsch -- Aurora kinase inhibitors / Mitesh J. Borad, Steven L. Warner, and Daniel D. von Hoff -- Apoptosis modulators : p53 targeting / Sunil Chada [and others] -- Survivin / Dario C. Altieri -- TRAIL modulators / C.H. Mom [and others] -- VEGF targeting / Lee M. Ellis -- Targeting angiogenesis with oral agents / Benjamin Besse and Jean-Pierre Armand -- Endothelial cell propagation targteing / Gordon C. Tucker -- HIF-1 inhibitors / Giovanni Melillo -- Antivascular agents / Jane Robertson -- Matrix metalloproteinases / Stéphane Vignot and Jean-Philippe Sapno -- Src inhibitors / Francisco Cruzalegui -- Telomerase and Telomere interacting agents / Jean-Franco̦i Riou [and others] -- Targeting Hsp90 : the cancer super-chaperone / Paul Workman and Swee Sharp |
| Summary |
Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treat |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Cancer -- Treatment.
|
|
Internal medicine.
|
|
Neoplasms -- therapy
|
|
Internal Medicine
|
|
HEALTH & FITNESS -- Diseases -- General.
|
|
MEDICAL -- Clinical Medicine.
|
|
MEDICAL -- Diseases.
|
|
MEDICAL -- Evidence-Based Medicine.
|
|
MEDICAL -- Internal Medicine.
|
|
Cancer -- Treatment
|
|
Internal medicine
|
| Form |
Electronic book
|
| Author |
Giaccone, Giuseppe
|
|
Soria, Jean-Charles
|
| ISBN |
9781420020588 |
|
1420020587 |
|
