| Description |
1 online resource |
| Contents |
Chapter 1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics / Zhoumeng Lin and Jeffrey W. Fisher -- Chapter 2. Introduction to classical pharmacokinetics / Shruti V. Kabadi and Zhoumeng Lin -- Chapter 3. Fundamentals of physiologically based pharmacokinetic modeling / Jeffrey W. Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand, Zhoumeng Lin -- Chapter 4. Physiologically based pharmacokinetic modeling software / C.E. Hack, A.Y. Efremenko, S.N. Pendse, Corie A. Ellison, A. Najjar, N. Hewitt, A. Schepky, H.J. Clewell -- Chapter 5. Chemical absorption and writing code for portals of entry / Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr, Darshan Mehta -- Chapter 6. Physiologically based pharmacokinetic model: distribution processes / Christopher Ruark -- Chapter 7. Metabolism and physiologically based pharmacokinetic models / Jeffrey W. Fisher, Jerry L. Campbell and Zhoumeng Lin -- Chapter 8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath / Sami Haddad and Andy Nong -- Chapter 9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis / Tammie R. Covington and Jeffery M. Gearhart -- Chapter 10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment / Zhoumeng Lin, Yi-Hsien Cheng, Wei-ChunChou, Miao Li -- Chapter 11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment / Lisa M. Sweeney and Jeffery M. Gearhart -- Chapter 12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment / Miyoung Yoon |
| Summary |
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. There are end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments |
| Notes |
Includes index |
|
Online resource; title from digital title page (viewed on July 28, 2020) |
| Subject |
Pharmacokinetics -- Simulation methods
|
|
Pharmacokinetics.
|
|
Pharmacokinetics
|
|
Pharmacokinetics
|
| Form |
Electronic book
|
| Author |
Fisher, Jeffrey W.
|
|
Gearhart, Jeffery M
|
|
Lin, Zhoumeng
|
| ISBN |
9780128196823 |
|
0128196823 |
|
