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Title The genetics of obesity / Struan F.A. Grant, editor
Published New York, NY : Springer, 2014

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Description 1 online resource (viii, 128 pages) : color illustrations
Contents Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies / Shana E. McCormack -- Genetic Obesity Syndromes / I. Sadaf Farooqi and Stephen O'Rahilly -- Genome-Wide Association Studies of Obesity / Åsa K. Hedman, Cecilia M. Lindgren and Mark I. McCarthy -- Copy Number Variants and Their Contribution to the Risk of Obesity / Julia Sarah El-Sayed Moustafa and Philippe Froguel -- Genetics of Childhood Obesity / Struan F.A. Grant -- Genetic Pleiotropies of Obesity / Bratati Kahali and Elizabeth K. Speliotes -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example / Stefanie Seehaus and Ulrich Rüther
Summary In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants
Notes Includes index
Bibliography Includes bibliographical references and index
Notes English
Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013)
In Springer eBooks
Subject Obesity -- Genetic aspects
Obesity -- genetics
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Obesity -- Genetic aspects
Genre/Form dissertations.
Academic theses
Academic theses.
Thèses et écrits académiques.
Form Electronic book
Author Grant, Struan F. A., editor
LC no. 2013950488
ISBN 9781461486428
1461486424
1306277884
9781306277884
1461486416
9781461486411