| Description |
1 online resource (382 pages) |
| Series |
Physiology in Health and Disease |
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Physiology in health and disease.
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| Contents |
Chapter 1: Introduction to Circadian Rhythms and Mechanisms of Circadian Oscillations; 1.1 Introduction to Circadian Rhythms; 1.2 Physiological Significance of Circadian Rhythms; 1.3 Health Consequences of Circadian Rhythm Disruption; 1.4 Overview of the Mammalian Circadian Timing System; 1.4.1 Input: Circadian Photoreception by the Retina; 1.4.2 The Master Circadian Pacemaker Is Located in the Suprachiasmatic Nuclei; 1.4.2.1 Neurochemical Interactions Among SCN Neurons; 1.4.2.2 Regulation of SCN Neuronal Excitability and Firing Rate |
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1.4.2.3 Transcription Factors Controlling Neuropeptide Expression Are Important for Circadian Rhythmicity1.4.3 SCN Outputs; 1.5 The Molecular Mechanisms Underlying Circadian Oscillation; 1.5.1 Overview; 1.5.2 Activation Phase; 1.5.3 Repression Phase; 1.5.4 Transcription Factor Cascades: Like Ripples on a Pond; 1.5.5 Interlocking Feedback Loops; 1.5.6 Setting Clock Speed by Regulation of Repressor Complex Stability; 1.5.7 A Myriad of Mechanisms for Transcriptional Modulation; 1.5.7.1 Transcription Factors and Cofactors; 1.5.8 Chromatin Remodeling and the Epigenetics of Circadian Timekeeping |
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1.5.8.1 Histone Phosphorylation1.5.8.2 Histone Acetylation and Deacetylation and the Link to Metabolism; 1.5.8.3 Histone Methylation; 1.5.8.4 Histone Substitution; 1.5.8.5 DNA Methylation; 1.5.9 Post-transcriptional Regulation of the Circadian Clock; 1.5.9.1 MicroRNAs; 1.5.9.2 Poly-A Tail Length; 1.5.9.3 Alternative Splicing and RNA-Binding Proteins; 1.6 Mutant Mouse Models: Past, Present, and Future; 1.7 Some Inconvenient Truths; 1.7.1 Circadian Rhythms in Locomotor Activity Can Exist in the Absence of a Functioning SCN; 1.7.1.1 The Food-Entrainable Oscillator |
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1.7.1.2 The Methamphetamine-Sensitive Circadian Oscillator1.7.1.3 Do the MASCO and the FEO Reflect the Same Mechanism?; 1.7.2 Circadian Biochemical Oscillations Exist in the Absence of Transcription; 1.7.3 Circadian Clock Proteins Sometimes Act in Unpredictable Ways; 1.8 Summary and Prospectus; References; Chapter 2: The Circadian Timing System and Endocrine Physiology; 2.1 Biological Clocks in Endocrine Physiology: Rhythms of Life; 2.2 The Circadian Timing System in Mammals; 2.3 The Circadian Timing System in Endocrine Physiology: From Pineal to Pancreas |
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2.4 Circadian Clock Function in the Hypothalamo-Pituitary-Adrenal (HPA) AxisHypothalamo-pituitary-adrenal (HPA) axis2.5 Circadian Clock Function in the Hypothalamo-Pituitary-Gonadal (HPG) AxisHypothalamo -- pituitary -- gonadal (HPG) axis; 2.5.1 Clock Function in Male Reproductive Physiology; 2.5.2 Circadian Clock Function in Female Reproductive Physiology; 2.6 Circadian Clock Function and the Endocrine Control of Bone Homeostasis; 2.7 Circadian Clock Function in the Mammalian Pineal Gland; 2.8 Circadian Clock Function and the Timing of Prolactin SecretionProlactin (PRL) secretion |
| Notes |
2.9 The Circadian Timing System and Endocrine Control of Metabolism |
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Print version record |
| Form |
Electronic book
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| ISBN |
9781493934508 |
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1493934503 |
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