Description |
1 online resource (xii, 80 pages) : illustrations (some color) |
Series |
Springer theses |
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Springer theses.
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Contents |
1. Introduction -- 2. The role of fragmentation on the formation of homomeric protein complexes -- 3. Collective response of self-organised clusters of mechanosensitive channels -- 4. Assembly and fragmentation of tat pores -- 5. Conclusion |
Summary |
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process |
Analysis |
Physics |
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Polymers |
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Cell membranes |
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Membranes |
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Membrane Biology |
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Statistical Physics, Dynamical Systems and Complexity |
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Polymer Sciences |
Bibliography |
Includes bibliographical references |
Subject |
Membrane proteins.
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Cell membranes
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Membrane Proteins
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Cell Membrane
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SCIENCE -- Life Sciences -- Biochemistry.
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Physique.
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Astronomie.
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Cell membranes
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Membrane proteins
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Form |
Electronic book
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ISBN |
9783642239885 |
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3642239889 |
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