Intro -- Haematology Lecture Notes -- Contents -- Preface to the first edition -- Preface to the ninth edition -- 1 An introduction to haematopoiesis -- Where is blood formed? -- Haemopoietic stem cells -- Differentiating blood cells -- Myelopoiesis -- Granulocytes and their function -- Monocytopoiesis and monocyte function -- Megakaryocytes and platelet function -- Erythropoiesis and red cell function -- Lymphopoiesis -- Summary -- 2 Anaemia: General principles -- Anaemia -- Symptoms and signs of anaemia -- The normal control of red cell production -- Morphological classification of anaemias
Microcytic anaemia: Iron handling and iron deficiency anaemia -- Iron absorption -- How does iron deficiency arise? -- The manifestations of iron deficiency -- Confirming a diagnosis of iron deficiency -- Treating iron deficiency -- Other causes of microcytic hypochromic anaemia -- Normocytic anaemia -- The anaemia of chronic disease -- Other causes of normocytic anaemia -- Macrocytic anaemia -- Causes of megaloblastic anaemia: vitamin B12 and folate deficiency -- How do B12 and folate deficiency arise? -- The clinical manifestations of B12 and folate deficiency
Confirming a diagnosis of B12 or folate deficiency -- Other causes of megaloblastosis -- Normoblastic macrocytosis -- Polycythaemia (erythrocytosis) -- True polycythaemia -- 3 Haemolytic anaemias -- Laboratory evidence of haemolysis -- Clinical features of haemolysis -- Classifying haemolytic anaemias and establishing a diagnosis -- Congenital haemolytic anaemias -- Haemolysis due to defects of the red cell membrane -- Haemolysis due to abnormalities of red cell enzymes -- Haemolysis due to haemoglobin defects -- Acquired haemolytic anaemias -- Immune haemolytic anaemias
Monocytosis -- Lymphocytosis and lymphopenia -- Transient lymphocytosis -- Persistent lymphocytosis -- Flow cytometry: A technique for identification of cells in suspension -- Infectious mononucleosis -- EBV infection -- CMV infection -- Toxoplasmosis -- HIV -- Leucoerythroblastic reaction -- 6 Structure and function of lymphoid tissue -- Lymph node structure -- Other lymphoid tissue -- Immunoglobulin structure and gene rearrangement -- Light chains -- Heavy chains -- Antibody diversity -- B-cell selection and maturation -- T-lymphocyte antigen receptors -- Natural killer cells
