| Description |
1 online resource |
| Contents |
Chapter 1: Introduction Section: Overview of Therapeutic Angiogenesis; Part I: Cell Therapy; Chapter 2: Autologous Bone Marrow Mononuclear Cell Implantation in Extremities with Critical Limb Ischemia; 2.1 Introduction; 2.2 Revascularization Therapy for Critical Limb Ischemia; 2.3 Mechanisms of Angiogenesis Through Cell Transplantation; 2.4 Indications for Autologous BMMNCs-Based Therapeutic Angiogenesis; 2.5 Details of Autologous BMMNCs Transplantation; 2.6 Clinical Trials of Therapeutic Angiogenesis Using Autologous BMMNCs |
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2.6.1 First Clinical Trial of Therapeutic Angiogenesis Using Autologous BMMNCs2.6.2 Long-Term Clinical Outcomes of Autologous BMMNCs-ƯBased Therapeutic Angiogenesis; 2.7 Persistence of the Effects Induced by Therapeutic Angiogenesis Treatment; 2.7.1 Drug Therapies Used in Combination with Revascularization Therapy; 2.8 Exercise Therapy for Ischemic Lower Limbs; 2.9 Points to Note for Cases with Frequent Cardiovascular Complications; 2.10 Indicators of Peripheral Blood Flow Improvement; 2.11 Issues in Therapeutic Angiogenesis; 2.12 Conclusion; References |
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Chapter 3: Peripheral Blood Mononuclear Cells for Limb Ischemia3.1 Introduction; 3.2 Pro-angiogenic Properties of PB-MNCs; 3.3 Clinical Studies of Unselected PB-MNCs for Limb Ischemia; 3.4 Clinical Studies Comparing BM-MNCs with PB-MNCs for Limb Ischemia; 3.5 Clinical Studies of PB-MNCs for Limb Ischemia; 3.6 Mechanisms of PB-MNC-Induced Neovascularization; 3.7 Modifiers of Cell Therapy; 3.7.1 Influence of Systemic Conditions; 3.7.2 Mobilizers; 3.7.3 Genetic Engineering; 3.7.4 Hypoxic Preconditioning; 3.7.5 Ultrasound; 3.7.6 Cell Scaffolds and Biomaterials |
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3.8 Conclusion and Future DirectionsReferences; Chapter 4: Endothelial Progenitor Cells for Ischemic Diseases; 4.1 Introduction; 4.2 Biological Characteristics and Definition of EPCs; 4.2.1 Tissue EPCs vs. Circulating EPCs; 4.2.2 Hematopoietic EPCs vs. Non-hematopoietic EPCs; 4.2.3 Colony-Forming EPCs vs. Non-colony-Forming EPCs; 4.2.3.1 Colony-Forming EPCs; 4.2.3.2 Non-colony-Forming EPCs; 4.3 EPC Mobilization and Kinetics in Peripheral Blood; 4.4 Role of EPCs in Postnatal Neovascularization; 4.5 EPC-Based Therapeutic Angiogenesis; 4.5.1 EPC Transplantation in Experimental Animals |
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4.5.2 EPC Transplantation in Clinical Trials4.5.3 Problems in EPC Transplantation; 4.6 EPC as a Biomarker for Ischemic Diseases; 4.7 Future Strategy with EPC Transplantation; 4.8 Summary; References; Chapter 5: Therapeutic Angiogenesis with Adipose Tissue-Derived Regenerative Cells; 5.1 Introduction; 5.2 Therapeutic Angiogenesis: Growth Factor and Cytokine Therapy; 5.3 Therapeutic Angiogenesis: Cell Therapy; 5.4 Adipose-Derived Stem/Progenitor Cells or Regenerative Cells; 5.5 Therapeutic Angiogenesis Using Adipose-Derived Regenerative Cells: A New Paradigm |
| Summary |
The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike |
| Bibliography |
Includes bibliographical references |
| Subject |
Neovascularization.
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Blood-vessels -- Diseases.
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Neovascularization, Physiologic
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Vascular Diseases
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Neovascularization, Pathologic
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Blood-vessels -- Diseases
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Neovascularization
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| Form |
Electronic book
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| Author |
Higashi, Yukihito
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Murohara, Toyoaki
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| ISBN |
9789811027444 |
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9811027447 |
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9789811096945 |
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9811096945 |
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9789811027451 |
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9811027455 |
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