| Description |
1 online resource |
| Contents |
Cover; Half Title; Title Page; Copyright Page; Table of Contents; Acknowledgements; Foreword; List of contributors; Chapter 1: Brain circuitry in ageing and neurodegenerative disease; Introduction; Cortico-basal ganglia and cortico-cerebellar circuits: structure and function; The ageing brain: changes in structure, function, and metabolic integrity; Structural changes in the aged brain; Functional changes in the aged brain; Differences in chronological versus brain age; Cortico-basal ganglia and fronto-cerebellar networks in ageing and neurodegeneration; Concluding remarks; Abbreviations |
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Further readingReferences; Chapter 2: Alzheimer's disease: prodromal stages and dementia; Introduction; Diagnostic considerations; Neuropathology and biomarkers; Prevalence and risk factors; Clinical vignette; Neuropsychology; Treatment and management; Concluding remarks; Abbreviations; Further reading; References; Chapter 3: Parkinson's disease; Introduction; Preliminary considerations; Clinical vignette; Diagnostic considerations; Biomarkers; Epidemiology; Genetics; Neuropsychology; Neuromodulation; Treatment; Concluding remarks; Abbreviations; Further reading; References |
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Chapter 4: Huntington's diseaseIntroduction; Prevalence; Clinical vignette; Diagnostic considerations; Genetics and gene testing; Juvenile-onset Huntington's disease; Neuropathology, neurophysiology and potential biomarkers; Clinical symptoms; Everyday functioning, care and health-related quality of life; Concluding remarks; Abbreviations; Further reading; References; Chapter 5: Experience-dependent modulation of neurodegenerative disorders: Huntington's disease as an exemplar; Introduction; Preclinical models of Huntington's disease; Experience-dependent modulators of Huntington's disease |
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Enviromimetics as a therapeutic lead for Huntington's diseaseConcluding remarks; Abbreviations; Notes; Further reading; References; Chapter 6: Fragile X-associated tremor ataxia syndrome; Introduction; Preliminary considerations; Clinical vignette; Onset and prevalence; Clinical signs and symptoms; Diagnostic instruments and clinical rating scales; Neuropsychology; Neuropathology/neurobiological mechanisms; Treatment including psychopharmacology; Concluding remarks; Abbreviations; Further reading; References; Chapter 7: Multiple sclerosis; Introduction; Preliminary considerations |
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EpidemiologyEtiology; Neuropathology; Clinical presentation; Diagnosis; Clinical course; Clinical vignette; Measures of disease status and progression; Treatment; Concluding remarks; Abbreviations; Further reading; References; Chapter 8: Dementia with Lewy bodies; Introduction; A brief epidemiology of dementia with Lewy bodies; Neuropathology; Clinical syndrome; Wakefulness in dementia with Lewy bodies; Concluding remarks; Abbreviations; Further reading; References; Chapter 9: Motor neuron disease; Introduction; Clinical vignette; Epidemiology; Clinical presentation; Prognosis |
| Summary |
Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer's disease and other dementias, Parkinson's disease and related disorders, and Huntington's disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on print version record |
| Subject |
Brain -- Degeneration.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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PSYCHOLOGY -- General.
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PSYCHOLOGY -- Neuropsychology.
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Brain -- Degeneration
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| Form |
Electronic book
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| Author |
Hocking, Darren R., editor
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Bradshaw, John L., 1940- editor.
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Fielding, Joanne, editor
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| LC no. |
2020694308 |
| ISBN |
9781351208895 |
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1351208896 |
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9781351208918 |
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1351208918 |
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9781351208901 |
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135120890X |
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9781351208888 |
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1351208888 |
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