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E-book

Title Comprehensive biomarker discovery and validation for clinical application / edited by Péter Horvatovich and Rainer Bischoff
Published Cambridge : Royal Society of Chemistry, 2013

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Description 1 online resource
Series RSC drug discovery ; v. 33
RSC drug discovery series ; v. 33.
Contents Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends
Summary This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks
Notes English
Title details screen (RSC Publishing; viewed on July 25, 2013)
Subject Biochemical markers.
Medical care.
Chemistry.
Public health.
Biology.
Physical sciences.
Biochemistry.
Liquid chromatography.
Proteomics.
Mass spectrometry.
Methodology.
Decision making -- Mathematical models.
Genomics.
Chromatographic analysis.
Statistics.
Life sciences.
Biological products.
Delivery of Health Care
Epidemiologic Methods
Medical Informatics Applications
Chemistry
Genetics
Chemicals and Drugs
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Medical Informatics
Public Health
Biology
Natural Science Disciplines
Quality of Health Care
Disciplines and Occupations
Health Care Quality, Access, and Evaluation
Environment and Public Health
Information Science
Biochemistry
Chromatography, Liquid
Data Interpretation, Statistical
Proteomics
Mass Spectrometry
Methods
Biomarkers
Biological Factors
Chemistry Techniques, Analytical
Decision Support Techniques
Investigative Techniques
Genomics
Chromatography
Statistics as Topic
Biological Science Disciplines
Health Care Evaluation Mechanisms
Computational Biology
Patient Care
chemistry.
public health.
biology.
physical sciences.
biochemistry.
liquid chromatography.
mass spectrometry.
methodology.
chromatography.
biological sciences.
statistics.
HEALTH & FITNESS -- Holism.
HEALTH & FITNESS -- Reference.
MEDICAL -- Alternative Medicine.
MEDICAL -- Atlases.
MEDICAL -- Essays.
MEDICAL -- Family & General Practice.
MEDICAL -- Holistic Medicine.
MEDICAL -- Osteopathy.
Statistics
Public health
Proteomics
Physical sciences
Methodology
Medical care
Mass spectrometry
Liquid chromatography
Life sciences
Genomics
Decision making -- Mathematical models
Chromatographic analysis
Chemistry
Biology
Biochemistry
Biochemical markers
Form Electronic book
Author Horvatovich, Péter, 1972- editor.
Bischoff, Rainer, 1956- editor.
ISBN 9781849734363
1849734364