Limit search to available items
Book Cover
E-book

Title Structure-based drug discovery / edited by Harren Jhoti, Andrew R. Leach
Published Dordrecht : Springer, [2007]
©2007
Online access available from:
Springer eBooks    View Resource Record  

Copies

Description 1 online resource (xii, 249 pages) : illustrations
Contents Front Matter; Five Years of Increasing Structural Biology Throughput -- A Retrospective Analysis; Protein Production for Structural Genomics -- Strategies for the Next Phase; Introduction to Fragment Screening; Fragment-Based NMR Screening in Lead Discovery; Fragment-Based Screening by X-ray Crystallography; Scaffold-Based Drug Discovery; Biophysical Methods; Illustration of Current Challenges in Molecular Docking; Scoring Functions; Back Matter
Summary Describes the developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Pharmaceutical technology.
Drugs -- Design -- Computer simulation.
Drugs -- Structure-activity relationships.
Proteins -- Structure.
Amino Acid Sequence.
Drug Design.
Drug Discovery.
Structure-Activity Relationship.
Technology, Pharmaceutical -- methods.
Computational Biology.
Form Electronic book
Author Jhoti, Harren.
Leach, Andrew R.
LC no. 2007464091
ISBN 1280902477
1402044062 (hardback ; alk. paper)
1402044070
661090247X
9781280902475
9781402044069 (hardback ; alk. paper)
9781402044076
9786610902477