In silico ADME/tox predictions / David Lagorce [and others] -- Absorption and physicochemical properties of the NCE / Jon Selbo and Po-Chang Chiang -- ADME / Martin E. Dowty [and others] -- Pharmacokinetics for medicinal chemists / Leo Kirkovsky and Anup Zutshi -- Cardiac toxicity / Ralf Kettenhofen and Silke Schwengberg -- Genetic toxicity : in vitro approaches for medicinal chemists / Richard M. Walmsley and David Elder -- Hepatic toxicity / Jinghai James Xu and Keith Hoffmaster -- In vivo toxicological considerations / John P. Devine Jr. --Pre-clinical candidate nomination and development / Nils Bergenhem -- Fragment-based drug design : considerations for good ADME properties / Haitao Ji
Summary
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as appl
