Title Handbook of basic pharmacokinetics-- including clinical applications / Wolfgang A. Ritschel, Gregory L. Kearns

Edition Seventh edition Published Washington, D.C. : American Pharmacists Association, [2009] ©2009

Copies

Location	Call no.	Vol.	Availability
MELB	615.7 Rit/Hob 2009		AVAILABLE

Description xii, 490 pages : illustrations ; 27 cm Contents 1 Definitions and nomenclature -- 2 The LADMER system - liberation, absorption, distribution, metabolism, elimination, and response -- 3 Organs, tissues, cells, and organelles -- 4 Cell membranes -- 5 Drug-receptor interactions -- 6 Absorption/transport mechanisms -- 7 PKa and degree of ionization -- 8 Lipid/water partition coefficient -- 9 Physicochemical and biological factors affecting in vivo performance of drugs -- 10 Biopharmaceutical data on the gastrointestinal tract -- 11 Fluid compartments and circulatory system -- 12 Binding of drugs to biological material -- 13 Drug biotransformation -- 14 Compartment models -- 15 Determination of rate constants -- 16 Volume of distribution and distribution coefficient -- 17 Excretion and clearance of drugs -- 18 Urinary and biliary recycling -- 19 Cumulative urinary excretion -- 20 Area under the blood level-time curve -- 21 Pharmacokinetics of single-dose administration -- 22 Pharmacokinetics of multiple dosing -- 23 Compartment-model-independent analysis -- 24 Pediatric pharmacokinetics -- 25 Drug dosage in elderly patients -- 26 Drug dosage in obese patients -- 27 Drug disposition in pregnancy -- 28 Dosage regimen design -- 29 Drug monitoring and dose adjustment -- 30 Physiologic and pathologic factors influencing drug response -- 31 First-does size in man -- 32 Forensic pharmacokinetics -- 33 Nonlinear pharmacokinetics -- 34 Curve fitting -- 35 Correlation of clinical response with drug disposition -- 36 Bioavailability and bioequivalence -- 37 Body surface areas -- 38 Extracorporeal methods of drug removal -- 39 Pharmacogenetics and pharmacogenomics -- Appendix: pharmacokinetic parameters of important drugs Summary Consolidation of pharmokinetic principles and techniques Bibliography Includes bibliographical references and index Subject Clinical pharmacology -- Handbooks, manuals, etc. Drugs -- Dosage -- Handbooks, manuals, etc. Pharmacokinetics -- Handbooks, manuals, etc. Pharmacokinetics. Genre/Form Handbook. Handbooks and manuals. Author Kearns, Gregory L. American Pharmacists Association. LC no. 2009020352 ISBN 1582121265 (hbk.) 9781582121260 (hbk.)

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