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Title Molecular carcinogenesis and the molecular biology of human cancer / edited by David Warshawsky, Joseph R. Landolph
Published Boca Raton : CRC, Taylor and Francis, 2006
Online access available from:
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Description 1 online resource (576 pages) : illustrations (some color)
Contents Carcinogens and mutagens -- Whole animal carcinogenicity bioassays -- Molecular mechanisms of action of selected organic carcinogens -- Binding of carinogens to DNA and covalent adducts and DNA damage -- PAH, aromatic amines, nitro-aromatic compounds, and halogenated compounds -- Cellular oncogenes and carcinogenesis -- Tumor suppressor genes -- Hepatitis B, Hepatitis C, and hepatocellular carcinoma -- Oncongenesis in transgenic and knockout mice -- Chemically induced morphological and neoplastic transformation in C3H/10T1/2 C1 8 mouse embryo cells -- Radiation carcinogenesis -- DNA microarrays and computational analysis of DNA microarray data in cancer research -- Application of proteomics in basic biological sciences and cancer -- Overview of human cancer induction and human exposure to carcinogens -- Complex mixtures of chemical carcinogens: principles of action and human cancer -- Lung cancer -- Breast cancer -- Cancer of the prostate -- Mechanisms of molecular carcinogenesis -- Skin cancer: epidemiology, clinical manifestations, and genetic and molecular aspects -- Cell and molecular biology of cancer of the brain --Thyroid cancer: molecular biology and clinical aspects -- Chemoprevention of chemical carcinogenesis and human cancer -- Carcinogen biomarkers and exposure assessment -- Risk assessment for chemical carcinogens -- Prevention and regulation approaches to carcinogens
Summary Providing an in-depth summary of the molecular aspects of carcinogenesis, this text comprehensively covers chemical, radiation, and viral carcinogenesis - from animal and human test data to metabolism and DNA binding. It reviews organic and metal carcinogenesis related to lung, breast, prostate, skin, liver, colon, brain, and thyroid cancers. The book explores the human implications of data regarding oncogenesis of transgenic and knockout mice and rats. It also covers the genomics and proteomics of chemoprevention, risk and exposure assessments, and regulation of carcinogens. Molecular Carcinogenesis is an ideal text for graduate courses in cancer
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cancer -- Molecular aspects.
Chemical carcinogenesis.
Neoplasms -- chemically induced.
Carcinogens -- toxicity.
Molecular Biology.
Form Electronic book
Author Landolph, Joseph R.
Warshawsky, David.
ISBN 0203503430 (electronic bk.)
9780203503430 (electronic bk.)
(alk. paper)