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Title Systems biology of apoptosis / Inna N. Lavrik, editor
Published New York, NY : Springer, [2013]
Online access available from:
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Description 1 online resource : illustrations (some color)
Contents Modeling Formalisms in Systems Biology of Apoptosis / Stefan Kallenberger and Stefan Legewie -- Systems Biology of Death Receptor-Induced Apoptosis / Kolja Schleich and Inna N. Lavrik -- Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis / Dennis Rickert, Nicolai Fricker, Inna N. Lavrik and Fabian J. Theis -- Systems Biology of the Mitochondrial Apoptosis Pathway / Jochen H.M. Prehn, Heinrich J. Huber and Carla O'Connor -- Systems Biology of Cell Death in Hepatocytes / Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer and Irmgard Merfort -- Understanding Different Types of Cell Death Using Systems Biology / Laurence Calzone, Andrei Zinovyev and Boris Zhivotovsky -- Modeling Single Cells in Systems Biology / Nicolai Fricker and Inna N. Lavrik -- Cytokine-Cytokine Cross Talk and Cell-Death Decisions / Christopher D. Deppmann and Kevin A. Janes -- Genetic and Genomic Dissection of Apoptosis Signaling / Christina Falschlehner and Michael Boutros
Summary Apoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death. In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies
Analysis Life sciences
Biological models
Systems Biology
Bibliography Includes bibliographical references and index
Subject Systems biology.
Systems Biology.
Form Electronic book
Author Lavrik, Inna N.
LC no. 2012943946
ISBN 9781461440093 (electronic bk.)
1461440092 (electronic bk.)
1461440084 (hard cover ; alk. paper)
9781461440086 (hard cover ; alk. paper)