| Description |
1 online resource |
| Contents |
Front Cover; Genes, Environment and Alzheimer's Disease; Copyright Page; Contents; List of Contributors; Foreword; Preface; Introduction; 1 Molecular Mechanisms of Learning and Memory; From Plato's Wax Tablet to Genes; Memory Processes; Brain Structures Underlying Memory Processes; Cellular Basis of Memory; The Role of CREB in Memory; Pathways Activating CREB; HDACs/HATs Role in Gene Transcription; References; 2 When Cognitive Decline Becomes Pathology: From Normal Aging to Alzheimer's Disease; Models of Cognitive Decline in Healthy Aging |
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Distinguishing AD-Associated Cognitive Decline from Normal AgingDistinguishing Preclinical AD from Normal Aging with Event-Related Potentials (ERPs); Memory Deficits in Preclinical AD; Deficits in Associative Memory; Deficits in Pattern Separation; Deficits in Recollection and Familiarity; Deficits in Prospective Memory; Deficits in Remote Memory; Deficits in Working Memory; Asymmetric Cognitive Decline in Preclinical AD; Summary and Conclusions; References; 3 Adult Neurogenesis and Cognitive Function: Relevance for Disorders Associated with Human Aging; Introduction |
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Identification and Characterization of Adult NeurogenesisDevelopment and Maturation of Adult-Born Neurons; Adult Mammalian Hippocampal Circuitry; Factors Affecting Adult Neurogenesis; Neurogenic Niche; Stress; Aging; Environmental Enrichment, Physical Activity, and Diet; Antidepressants and Mood-Stabilizing Treatments; Proposed Functions of Adult Neurogenesis; Pattern Separation; Other Aspects of Spatial and Contextual Memory; Regulation of Mood and the HPA-Axis; Neurogenesis, Hippocampal Dysfunction, and Alzheimer's Disease; Proteins Linked to FAD Regulate Neurogenesis |
| Summary |
This volume explores the interplay between genetic and environmental risk factors in the induction of cognitive decline and the development of dementia-related diseases such as Alzheimer's |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed March 9, 2016) |
| Subject |
Alzheimer's disease.
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Alzheimer's disease -- Molecular aspects
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Alzheimer's disease -- Genetic aspects
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Alzheimer Disease
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Alzheimer's disease
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Alzheimer's disease -- Genetic aspects
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Alzheimer's disease -- Molecular aspects
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| Form |
Electronic book
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| Author |
Lazarov, Orly, editor
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Tesco, Giuseppina, editor
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| ISBN |
9780128028858 |
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0128028858 |
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0128028513 |
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9780128028513 |
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