| Description |
1 online resource |
| Contents |
Intro -- Preface -- Contents -- Contributors -- Chapter 1: Why Study Drug-Resistant Epilepsy? -- References -- Chapter 2: Pharmacoresistance in Epilepsy -- 2.1 Epilepsy -- 2.2 Epilepsy as Stigma -- 2.3 Epilepsy and Pharmacoresistance -- 2.4 Epilepsy as Health Problem -- 2.5 Burden of Pharmacoresistant Epilepsy -- 2.6 Epilepsy Care -- 2.7 Conclusion -- References -- Chapter 3: Experimental Models for the Study of Drug-Resistant Epilepsy -- 3.1 Introduction -- 3.2 In Vitro Models -- 3.2.1 Cell Cultures -- 3.2.2 Brain Slices with Cortical Dysplasia Exposed to 4-Aminopyridine |
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3.2.3 In Vitro Study of Brain Tissue from Patients with Drug-Resistant Epilepsy -- 3.3 In Vivo Models of Drug-Resistant Seizures -- 3.3.1 Caenorhabditis Elegans -- 3.3.2 Zebrafish -- 3.4 Induction of Drug-Resistant Seizures by Repeated Administration of Proconvulsant Drugs -- 3.5 Chemical Kindling and Drug Resistance -- 3.6 Electrical Kindling and Drug Resistance -- 3.7 Corneal Electric Kindling -- 3.8 Models of Drug-Resistant Epilepsy -- 3.8.1 Drug-Resistant Epilepsy Secondary to Status Epilepticus Due to Lithium-Pilocarpine -- 3.8.2 Kainic Acid and Drug-Resistant Epilepsy |
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3.8.3 Models of Drug-Resistant Posttraumatic Epilepsy -- 3.8.4 Canines with Drug-Resistant Epilepsy -- 3.9 Models of Drug-Resistant Epilepsy Due to Genetic Alterations -- 3.10 Novel Approaches to Assess Drug-Resistant epilepsy in Animal Models -- 3.11 Epilepsy Therapy Screening Program: Advantages and Limitations for the Detection of Therapies for Drug-Resistant Epilepsy -- 3.12 Conclusions -- References -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- 4.1 Introduction -- 4.2 Emergence: Linking Multiple Hypotheses of DRE |
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4.3 The Role of Comorbidities in DRE -- 4.4 Systems Biology: Dealing with the Multiple Mechanisms of DRE -- 4.5 The Advent of Systems Pharmacology for the Treatment of Epilepsy -- 4.6 Conclusion -- References -- Chapter 5: The Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- 5.1 Introduction -- 5.2 Different Types of HFO in Normal Brain and the Brain with Focal Epilepsy -- 5.3 Mechanisms Generating Normal and Pathological HFO and the Contributions of Inhibitory and Excitatory Cells -- 5.4 Fast Ripples as Biomarkers of Epileptogenic Tissue |
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5.5 Proposed Roles of FR in Surgical Planning -- 5.6 Utilizing FR Graph Theoretical Metrics to Assess the Epileptogenic Network for Surgical Planning -- 5.7 Stimulation Therapy of the Epileptogenic Network -- 5.8 Summary -- References -- Chapter 6: Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level? -- 6.1 Introduction -- 6.2 The Multidrug Resistance (MDR) Phenotype -- 6.3 Role of ABC-t in the "LADME System" as the Peripheral Mechanism of Drug Resistance in Epilepsy -- 6.4 ABC-t in the Central Mechanism of Drug-Resistant Epilepsy |
| Summary |
This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on online resource; title from digital title page (viewed on October 05, 2023) |
| Subject |
Drug resistance.
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Epilepsy -- Chemotherapy
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Epilepsy -- Treatment
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Drug Resistance
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Drug resistance.
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Epilepsy -- Chemotherapy.
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Epilepsy -- Treatment.
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| Form |
Electronic book
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| Author |
Rocha, Luisa.
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Lazarowski, Alberto.
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Cavalheiro, Esper A.
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| ISBN |
9783031365263 |
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3031365267 |
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