Title Lung disease in rheumatoid arthritis / Aryeh Fischer, Joyce S. Lee, editors

Published Cham, Switzerland : Humana Press, 2018

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Description 1 online resource (x, 178 pages) : illustrations (some color) Series Respiratory medicine, 2197-7372 Respiratory medicine (New York, N.Y.), 2197-7372 Contents Intro; Preface; Contents; Contributors; Chapter 1: Clinical Overview of Rheumatoid Arthritis; Etiology; Genetic Factors; Environmental Factors; Host Factors; Pathogenesis; Epidemiology; Clinical Presentation: Early Arthritis and Periarthritis; Clinical Manifestations: Late Articular and Periarticular Sequelae; Extra-Articular Manifestations; Laboratory Findings; Radiographic Imaging; Diagnosis, Classification Criteria, and Differential Diagnosis; Clinical Variants; Disease Activity and Disability Measures; Treatment; Prognosis: Morbidity and Mortality; References Chapter 2: Rheumatoid Arthritis Pathogenesis and PathophysiologyRA Etiology; Genetic Risk; Evolution of the RA Immune Response; Humoral Immunity; Role of T Cells; B Cells; Cytokines as the Final Common Pathway in RA Pathophysiology; Extra-Articular Manifestations of RA; References; Chapter 3: The Lungs as the Site of Initiation of RA; Introduction; Preclinical RA; Autoantibody and Inflammatory Evolution in Preclinical RA; The Natural History of RA Suggests That Initial Autoimmunity Starts Outside of the Joints The Lung Is a Particularly Important Site of Possible Initiation of RABiologic Machinery Within the Lung to Generate Immune (and Autoimmune) Responses; Epidemiologic Data Linking Inhaled Factors to Risk for RA; Lung Disease in the Absence of or Preceding Synovitis in RA; Generation of RA-Related Autoimmunity Within the Lung in the Absence of Synovitis; Putting It All Together: A Model of RA Where Autoimmunity Starts in the Lung and Later Involves the Joints; Future Directions; Conclusion; References Chapter 4: The Epidemiology of Rheumatoid Arthritis-ÂƯAssociated Lung DiseaseIntroduction; Challenges of Epidemiologic Studies in RA Lung Disease; Rheumatoid Arthritis-Associated Interstitial Lung Disease; Prevalence and Cumulative Incidence of RA-ILD in Patients Known to Have RA (Table 4.1); Prevalence of RA-ILD in Patients with Respiratory Symptoms; Prevalence of RA-ILD in Unselected Patients; Prevalence of RA-ILD Using CXR, Pulmonary Function Tests (PFTs), and Multimodality Approach; Risk Factors for RA-ILD (Table 4.2); Smoking; Sex; Age; RA Disease Activity RA Disease DurationRA Treatment; Genetics; RA-Related Antibodies; Rheumatoid Arthritis-Associated Airways Disease; Prevalence and Cumulative Incidence of Airways Disease in RA (Table 4.3); Rheumatoid Arthritis-Associated Pleural Disease; Summary; References; Chapter 5: Risk Factors and Biomarkers of RA-ILD; Introduction; RA-ILD Phenotypes; Risk Factors; Biomarkers; Autoantibodies; Experimental Serum Biomarkers; Alveolar Protein Biomarkers; Other Potential Markers of RA-ILD; Clinical Predictive Modeling; Conclusion; References; Chapter 6: Thoracic Imaging in Rheumatoid Arthritis Summary This book addresses the manifestation of lung disease in patients with rheumatoid arthritis (RA). Lung disease in RA is common and often associated with significant morbidity and mortality. This stems partially from the nature of RA and partially from the many therapies used to manage RA that are associated with pneumotoxicity. Despite the severity and commonality of this comorbidity, little has been written on the topic. This book thus takes a multidisciplinary approach to provide: a concise overview of RA and why lung disease so commonly coincides with it; overviews of the specific lung diseases, including interstitial lung disease, and their epidemiology, associated imaging, histopathology, biomarkers, and management; a presentation of risk factors for these diseases; and specifics on what still needs to be uncovered about these pulmonary manifestations. Lung Disease in Rheumatoid Arthritis is a comprehensive and practical resource for clinicians and clinician scientists in pulmonology, rheumatology, pathology, and primary care Notes Includes index Online resource; title from PDF title page (SpringerLink, viewed February 20, 2018) Subject Rheumatoid arthritis. Lungs -- Diseases. Arthritis, Rheumatoid Lung Diseases Rheumatology. Intensive care medicine. Respiratory medicine. HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Lungs -- Diseases Rheumatoid arthritis Form Electronic book Author Fischer, Aryeh, editor. Lee, Joyce S., editor ISBN 9783319688886 331968888X

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