| Description |
1 online resource (x, 171 pages) : illustrations (chiefly color) |
| Contents |
Intro -- Preface -- Contents -- Editors and Contributors -- About the Editors -- Contributors -- Chapter 1: Epidemics of Hand, Foot, and Mouth Disease -- 1 Introduction -- 2 HFMD Epidemiology -- The 1970s-1980s -- Europe -- Asia -- Oceania -- The Americas -- 1990-1999 -- Europe -- Asia -- Oceania -- The Americas -- 2000-2015 -- Europe -- Asia -- Oceania -- America -- 2016 to the Present -- Europe -- Asia -- The Americas -- 3 Variety of Circulating Viruses -- EV-A71 is a Major Pathogen Leading to Severe and Fatal Cases -- HFMD Pathogens Tend to Exhibit Great Variability |
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4 HFMD Epidemic Cycle -- References -- Chapter 2: Etiology of HFMD -- 1 Enteroviruses (EVs) -- Discovery of EVs -- CV-A -- CV-B -- ECHO Viruses -- Structure and Physical and Chemical Features of EVs -- Evolution of EVs -- Classifications of EVs -- 2 EV-Associated Diseases -- Hand, Foot, and Mouth Disease -- Poliomyelitis -- Other Diseases -- 3 Common Pathogens of HFMD -- EV-A71 -- Discovery of EV-A71 -- Structure and Genomic Features of EV-A71 -- Genogroups and the Evolution of EV-A71 -- EV-A71-Associated Diseases -- CV-A16 -- Discovery of CV-A16 |
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Structural and Genomic Characteristics of CV-A16 -- Genotypes of CV-A16 -- CV-A16-Associated Diseases -- EV-A71 and CV-A16 Cocirculation -- Other Enteroviruses -- 4 Rapid Diagnosis and Genotyping of EV Infection -- References -- Chapter 3: Mechanisms Underlying HFMD Clinical Pathology in Children -- 1 Clinical Manifestations of HFMD -- Typical Mild HFMD in Children -- Atypical HFMD in Children -- Fatal HFMD in Children -- 2 HFMD Pathogenesis -- Biological Features of Enteroviruses and HFMD Development -- Etiology of Enterovirus Infection -- Unique EV-A71 Structure and Related Pathogenicity |
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Host Gene Susceptibility and HFMD -- OAS Genes -- HLA Gene -- Receptors Involved in Viral Interactions with Host Cells -- Host Immune Response and HFMD -- Viral Infection and Innate Immune Escape -- HFMD and the Inflammatory Response -- Oxidative Stress (OS) Signaling -- NF-kB Signaling -- Epidermal Growth Factor Receptor (EGFR) Signaling -- Mitogen-Activated Protein Kinase (MAPK) Signaling -- Phosphatidylinositol 3-Kinase (PI3K) Signaling -- Calcium (Ca2+)-Dependent Signaling -- Cytokines Associated with the Development of HFMD -- Viral Infection and Host Pathological Injury -- Autophagy |
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Apoptosis -- 3 Pathogenesis of HFMD-Associated Disease -- Pathogenesis of HFMD-Associated Skin Rash and Blisters -- Pathogenesis of HFMD-Complicated CNS Disorders -- Direct Pathogenicity Induced by Viral Infection -- Immune Injury -- Inflammatory Injury -- Pathogenesis of HFMD-Complicated Neurogenic PE -- Pathogenesis of HFMD-Complicated Injury of Other Organs -- Pathogenesis of HFMD-Complicated Myocardium Injury -- Pathogenesis of HFMD-Complicated Gastrointestinal Injury -- Pathogenesis of HFMD-Complicated Acute Kidney Injury -- Pathogenesis of HFMD-Complicated Acute Liver Injury -- 4 Conclusion |
| Summary |
This book aims to compile the latest scientific information on hand, foot, and mouth disease (HFMD), including its epidemiology, etiology, pathology, immune response and vaccine development. Interestingly, the authors shared their own research experience and offered distinctive insights into the pathogenesis of HFMD and vaccine development. The intended audience, including university researchers, graduate students, and vaccine engineers, is well defined. The book is positioned as a resource that not only presents current knowledge but also has the potential to inspire further research in understanding immune pathogenesis and advancing vaccine development for HFMD |
| Notes |
Description based upon print version of record |
| Bibliography |
References |
| Subject |
Enterovirus diseases -- Molecular aspects
|
| Genre/Form |
Electronic books
|
| Form |
Electronic book
|
| Author |
Xu, Xingli
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Che, Yanchun
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Li, Qihan
|
| ISBN |
9789819996605 |
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9819996600 |
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