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Title Molecular and cellular aspects of the serpinopathies and disorders in serpin activity / editors, Gary A. Silverman, David A. Lomas
Published Hackensack, NJ : World Scientific Pub., [2007]
©2007
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Description 1 online resource (xxi, 639 pages) : illustrations (some color)
Contents SECTION I OVERVIEW OF THE SERPIN SUPERFAMILY; SECTION II LESSONS FROM MODEL ORGANISMS; SECTION III SERPIN PHYSIOLOGY AND PATHOPHYSIOLOGY; SECTION IV CONGENITAL DEFICIENCIES AND SERPINOPATHIES; Editors; Contributors; Serpinopathies Foreword; Serpinopathies Preface; Index
Summary Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Ma
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Serpins -- Physiological effect.
Serpins.
Serpins.
Form Electronic book
Author Lomas, David A.
Silverman, Gary A.
ISBN 9789812707543 (electronic bk.)
9812707549 (electronic bk.)