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Uniform Title Lysosomes (Maxfield)
Title Lysosomes : biology, diseases, and therapeutics / edited by Frederick R. Maxfield, James M. Willard, Shuyan Lu
Published Hoboken, New Jersey : John Wiley & Sons, Inc., [2016]
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Description 1 online resource
Contents Lysosomes an introduction / Frederick R. Maxfield -- Lysosome biogenesis and autophagy / Fulvio Reggiori, Judith Klumperman -- Multivesicular bodies: roles in intracellular and intercellular signalling / Emily R. Eden, Thomas Burgoyne, Clare E. Futter -- Lysosomes and mitophagy / Dominik Haddad, Patrik Verstreken -- Lysosome exocytosis and membrane repair / Rajesh K. Singh, Abigail S. Haka -- Role of lysosomes in lipid metabolism / Frederick R. Maxfield -- TFEB, master regulator of cellular clearance / Graciana Diez-Roux and Andrea Ballabio -- Lysosomal membrane permeabilization in cell death / Urska Repnik, Boris Turk -- The lysosome in aging-related neurodegenerative diseases / Ralph A. Nixon -- Lysosome and cancer / Marja Jaattela and Tuula Kallunki -- The genetics of sphingolipid hydrolases & sphingolipid storage diseases / Edward H. Schuchman and Calogera M. Simonaro -- Lysosome-related organelles : modifications of the lysosome paradigm / Adriana R. Mantegazza and Michael S. Marks -- Autophagy inhibition as a strategy for cancer therapy / Xiaohong Ma, Shengfu Piao, Quentin Mcafee, and Ravi K. Amaravadi -- Autophagy enhancers, are we there yet? / Shuyan Lu & Ralph A Nixon -- Pharmacological chaperones as potential therapeutics for lysosomal storage disorders: preclinical research to clinical studies / Robert E. Boyd, Elfrida R. Benjamin, Su Xu, Richie Khanna, and Kenneth J. Valenzano -- Endosomal escape pathways for delivery of biologics / Philip L. Leopold -- Lysosomes and antibody drug conjugates / Michelle Mack, Jennifer Kahler, Boris Shor, Michael Ritchie, Maureen Dougher, Matthew Sung, and Puja Sapra -- The mechanisms and therapeutic consequences of amine-containing drug sequestration in lysosomes / Nadia Hamid and Jeffrey P. Krise -- Lysosome dysfunction : an emerging mechanism of xenobiotic-induced toxicity / Shuyan Lu, Bart Jessen, Yvonne Will & Greg Stevens -- Lysosomes and phospholipidosis in drug development and regulation / James M. Willard and Albert De Felice
Summary Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.- Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates - Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair- Introduces new pathways in therapeutic development and new mechanisms in drug development
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Lysosomes.
Lysosomes.
Form Electronic book
Author Lu, Shuyan, 1971- editor
Maxfield, Frederick R., editor
Willard, James M., 1955- editor
LC no. 2016008790
ISBN 1118645154 (cloth)
1118978307 (pdf)
1118978315 (epub)
1118978323 (electronic bk.)
9781118645154 (cloth)
9781118978306 (pdf)
9781118978313 (epub)
9781118978320 (electronic bk.)
(cloth)