| Description |
1 online resource |
| Contents |
Function of Filaggrin and Its Metabolites -- Morphology of Filaggrin-Depleted Epidermis -- Stratum Corneum Lipids and Filaggrin -- Inflammatory-Driven Depletion of Filaggrin Proteins -- Immune Activity and Vitamin D -- Filaggrin-2 -- Animal Models -- In Vitro Models of Filaggrin-Associated Diseases -- Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics -- Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy -- Filaggrin Genotyping -- Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective -- Filaggrin Gene Mutations in Asian Races -- Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals -- Filaggrin Mutations and the Atopic March -- Atopic Dermatitis -- Asthma -- Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis -- Filaggrin and Non-cutaneous Disease: Food Allergy -- Filaggrin in Canine Skin -- Ichthyosis Vulgaris and Other Disorders of Cornification -- Xerosis Means "Dry Skin": Mechanisms, Skin Conditions, and Its Management -- Allergic Contact Dermatitis -- Irritant Contact Dermatitis -- Hand Eczema -- Filaggrin in Psoriasis -- Filaggrin and Skin Infections -- Atopic Dermatitis and Skin Cancer -- Filaggrin Gene Mutations: A Clinician's Perspective -- Filaggrin, the Skin Barrier, and Diabetes -- The Eye and Filaggrin -- Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract -- Filaggrin, Human Papillomavirus, and the Cervix -- Antibodies Against Citrullinated Proteins and Filaggrin -- Filaggrin and the Oral Mucosa -- Therapeutics and Other Interventions |
| Summary |
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Skin -- Diseases -- Genetic aspects.
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Medical genetics.
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Skin Diseases -- genetics
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Genetics, Medical
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HEALTH & FITNESS -- Diseases -- General.
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HEALTH & FITNESS -- Diseases -- Skin.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Medical genetics
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Skin -- Diseases -- Genetic aspects
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| Form |
Electronic book
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| Author |
Thyssen, Jacob P., editors.
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Maibach, Howard I., editors.
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| ISBN |
9783642543791 |
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3642543790 |
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9783642543807 |
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3642543804 |
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9783662511176 |
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3662511177 |
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