| Description |
1 online resource |
| Contents |
Preface; Contents; Contributors; Part I Basic Principles of Patho-epidemiology ; 1 The Intersection of Epidemiology and Pathology; 1.1 The Intersection of Pathology and Epidemiology; 1.2 Examples from the Intersection of Epidemiology and Pathology; 1.2.1 Breast Cancer; 1.2.2 Prostate Cancer; 1.2.3 Glioblastoma; 1.2.4 Hematologic Malignancies; 1.2.5 Colorectal Cancer; 1.2.6 Genome-Wide Association Studies; 1.3 Summary; References; 2 Introduction to Histology; 2.1 Introduction to Histology; 2.2 Specimen Types; 2.3 Specimen Examination and Sampling; 2.4 Preparation of Histological Slides |
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2.4.1 Fixation of Tissue2.4.2 Processing of Tissue; 2.4.3 Sectioning of Tissue; 2.5 Staining of Tissue; 2.5.1 Immunohistochemistry; 2.5.2 In Situ Hybridization; 2.6 The Frozen Section; 2.7 Tissue Microarray Construction and Evaluation; 2.8 Microscopes, Automated Imaging, and Digital Software; 2.9 The Normal Human Cell and its Components; 2.9.1 The Cytoplasm and its Organelles; 2.9.2 The Nucleus and Gene Expression; 2.10 Basic Histology of Normal Tissues; 2.10.1 Epithelia; 2.10.2 Connective Tissues; 2.10.3 Muscles; 2.10.4 Neural Tissues; 2.11 Summary; References; 3 Introduction to Pathology |
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3.1 Introduction to Pathology3.2 Formation of Tissues and Organ Systems; 3.3 Germ Layer Derivatives; 3.3.1 Ectoderm; 3.3.2 Mesoderm; 3.3.3 Endoderm; 3.4 Cellular Adaptation and Death; 3.4.1 Atrophy; 3.4.2 Hypertrophy and Hyperplasia; 3.4.3 Metaplasia; 3.4.4 Cell Death: Necrosis and Apoptosis; 3.5 Dysplasia and Carcinoma In Situ; 3.6 Neoplasia; 3.6.1 Benign Tumors; 3.6.2 Malignant Tumors; 3.7 Important Biological Characteristics of Solid Tumors; 3.7.1 Proliferative Activity; 3.7.2 Tumor Stroma; 3.7.3 Tumor Tissue Heterogeneity; 3.7.4 Epithelial-Mesenchymal Transition; 3.8 Stage of Disease |
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3.9 SummaryReferences; 4 Basic Techniques in Molecular Pathology; 4.1 Introduction; 4.2 Material (Tissue) Selection; 4.2.1 Cell Culture; 4.2.2 Direct Human Samples; 4.2.2.1 Fluids; 4.2.2.2 Tissue; Fresh/Frozen Tissue; Formalin-Fixed Paraffin-Embedded Tissue; Other Fixatives Used in Pathology; 4.3 Nucleic Acid Purification; 4.3.1 Type of Tissue Isolation; 4.4 Analysis; 4.4.1 Focused Analytical Techniques; 4.4.1.1 Quantitative Real-Time Polymerase Chain Reaction; 4.4.1.2 Mutation-Specific PCR; 4.4.1.3 In Situ Hybridization; 4.4.2 Broad Analytical Techniques; 4.4.2.1 Microarrays; DNA Arrays |
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RNA Expression Arrays4.4.2.2 Sequencing; Sanger Sequencing; Massively Parallel Sequencing; Presequencing; Sequencing; Post-Sequencing; Uses of Massively Parallel Sequencing; Other MPS Techniques; Conclusions; 4.5 Summary; References; 5 Introduction to Cancer Epidemiology; 5.1 What Is Epidemiology?; 5.2 Measures of Disease Occurrence; 5.3 Exposure and Outcome; 5.4 Measures of Association; 5.5 Study Population; 5.6 Study Design; 5.6.1 Experimental Studies; 5.6.2 Observational Studies; 5.7 Bias and Confounding; 5.8 Summary: Epidemiological Methods as a Toolbox; References; 6 Cancer Screening |
| Summary |
Pathology and Epidemiology of Cancer integrates the disciplines of Cancer Pathology and Epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease, inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention. |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed September 15, 2016) |
| Subject |
Cancer -- Epidemiology.
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Carcinogenesis.
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Neoplasms -- pathology
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Neoplasms -- epidemiology
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Carcinogenesis
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Medical research.
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Pathology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer -- Epidemiology
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Carcinogenesis
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| Form |
Electronic book
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| Author |
Loda, Massimo, editor
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Mucci, Lorelei A., editor
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Mittelstadt, Megan L., editor
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Hemelrijck, Mieke Van, editor
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Cotter, Maura Bríd, editor
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| ISBN |
9783319351537 |
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3319351532 |
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