| Description |
1 online resource (xiii, 605 pages) : illustrations |
| Series |
BIOSCIENCEnetBASE
|
| Contents |
An introduction and overview / Steven M. Colegate and Russell J. Molyneux -- Detection and isolation of bioactive natural products / Emilio L. Gisalberti -- Nuclear magnetic resonance spectroscopy: strategies for structural determination / Lindsay T. Byrne -- Quantitative NMR of bioactive natural products / Guido F. Pauli [and others] -- Development and application of LC-NMR techniques to the identification of bioactive natural products / Jean-Luc Wolfender, Emerson F. Queiroz, and Kurt Hostettmann -- Determination of the absolute configuration of bioactive natural products using exciton chirality circular dichroism / Hans-Ulrich Humpf -- Separation of enantiomeric mixtures of alkaloids and their biological evaluation / Stephen T. Lee, Russell J. Molyneux, and Kip E. Panter -- Dereplication and discovery of natural products by UV spectroscopy / Thomas O. Larsen and Michael A.E. Hansen -- Liquid chromatography-mass spectrometry in natural product research / Ka-Wing Cheng, Feng Chen, and Mingfu Wang -- Application of high-speed countercurrent chromatography to the isolation of bioactive natural products / Huabin Li and Feng Chen -- Biosensing approach in natural product research / Maria Minunni and Anna R. Bilia -- Anticancer drug discovery and development from natural products / Gordon M. Cragg and David J. Newman -- Sourcing natural products from endophytic microbes / Gary Strobel and Uvidelio Castillo -- Isolation of bioactive natural products from myxobacteria / Makoto Ojika -- Naturally occurring glycosidase inhibitors / Robert J. Nash -- Bioassay-directed isolation and identification of antiaflatoxigenic constituents of walnuts / Russell J. Molyneux [and others] -- Bioactive peptides in hen eggs / Yoshinori Mine and Icy D'Silva -- Biological fingerprinting analysis: strategy for screening bioactive compounds in traditional Chinese medicines / Xingye Su [and others] -- Antimalarial compounds from traditionally used medicinal plants / Lengo Mambu and Philippe Grellier -- Germination stimulant in smoke: isolation and identification / Gavin R. Flematti [and others] -- Plant-associated toxins: bioactivity-guided isolation, ELISA, and LC-MS detection / Teven M. Colegate |
| Summary |
Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the successful detection, isolation, and structure determination of specific compounds. The text encompasses a diverse range of techniques that can be applied to terrestrial and aquatic sources. It also allows you to understand how source material can be selected to enhance your opportunity to discover and utilize novel bioactive natural products. New to the Second Edition: *Advances in the application of NMR spectroscopy and mass spectrometry, bioactive chemical detection and extraction, dereplication, and novel bioassay development *New case studies and illustrations that demonstrate the practical applications of specific techniques *A group of new contributors presenting research from their own laboratories that emphasize both the philosophy and rationale behind detection, isolation, and structural determination. Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. With the participation from active researchers, this definitive work supplies a vital extension and an enduring contribution to the science and art of bioactive natural product detection, isolation, and structural determination.--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Natural products.
|
|
Bioactive compounds.
|
|
Biologicals.
|
|
Biological products.
|
|
Biological Products
|
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Phytotherapy
|
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Plants, Medicinal -- chemistry
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Biological Factors
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SCIENCE -- Life Sciences -- Biochemistry.
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Bioactive compounds
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Natural products
|
| Form |
Electronic book
|
| Author |
Colegate, Steven M.
|
|
Molyneux, Russell J.
|
| LC no. |
2007010056 |
| ISBN |
9781420006889 |
|
1420006886 |
|
9780429127540 |
|
0429127545 |
|
