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Title Epigenetics of aging and longevity / [edited by] Alexey Moskalev, Alexander M. Vaiserman
Published London ; San Diego, CA ; Cambridge, MA : Academic Press, 2017
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Description 1 online resource
Series Translational epigenetics series ; volume 4
Translational epigenetics series ; volume 4
Contents Aging epigenetics : changes and challenges / Duygu Ucar and Bérénice A. Benayoun -- Defective DNA methylation/demethylation processes define aging-dependent methylation patterns / Michele Zampieri, Fabio Ciccarone, Paola Caiafa -- S-adenosylmethionine metabolism and aging / Wil A.M. Loenen -- The epigenetic clock and aging / Ken Raj -- The epigenetic regulation of telomere maintenance in aging / Huda Adwan-Shekhidem and Gil Atzmon -- Living long and aging well : are lifestyle factors the epigenetic link in the longevity phenotype? / Irene Maeve Rea and Ken I. Mills -- Epigenetic biomarkers for biological age / Arnold B. Mitnitski -- The role of non-coding RNAs in genome stability and aging / Igor Kovalchuk -- Intra-tissue DNA methylation heterogeneity in aging / Jan Vijg, Silvia Gravina, Xiao Dong -- Early-life nutrition, epigenetics and altered energy balance later in life / Clare M Reynolds, Justin M O'Sullivan, Stephanie A. Segovia, Mark H. Vickers -- Early nutrition, epigenetics and human health / Simon C. Langley-Evans and Beverly S. Muhlhausler -- Biological embedding of psychosocial stress over the life course / Helen Eachus and Vincent T. Cunliffe -- Epigenetics of longevity in social insects / Alexander M. Vaiserman, Oleh V. Lushchak and Alexander K. Koliada -- Drosophila melanogaster as a model for studying the epigenetic basis of aging / Ilya Solovyov, Mikhail Shaposhnikov, Anna Kudryavtseva, Alexey Moskalev -- Histone modification changes during aging : cause or consequence? What we have learned about epigenetic regulation of aging from model organisms / Xiaohua Cao and Weiwei Dang -- Epigentics of brain/cognitive aging / Xiangru Xu -- The role of epigenetic modifications in cardiometabolic diseases / Kim V.E. Braun, Eliana Portilla, Rajiv Chowdhury, Jana Nano, Jenna Troup, Trudy Voortman, Oscar H. Franco, Taulant Muka -- Epigenetic mechanisms in osteoporosis / Barbara Ostanek, Tilen Kranjc, Nika Lovšin, Janja Zupan, Janja Marc -- Epigenetics of skeletal muscle aging / Adam P. Sharples, Robert A. Seaborne, Claire E. Stewart -- Healthy aging and epigenetic drugs for diabetes and obesity : a novel perspective / Sunitha Meruvu, John D. Bowman, Mahua Choudhury -- Epigenetic drugs for cancer and precision medicine / Mukesh Verma, Vineet Kumar -- Epigenetic drug discovery for Alzheimer's disease / Ramón Cacabelos, Oscar Teijido -- Epigenetics of aging and longevity : challenges and future directions / Axel Schumacher
Summary Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related diseaseProvides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectoryApplies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
Notes Includes index
Vendor-supplied metadata
Subject Aging -- Genetic aspects.
Form Electronic book
Author Moskalev, A. A. (Alekseĭ Aleksandrovich), 1976- editor
Vaiserman, Alexander, editor
ISBN 012811083X (electronic bk.)
9780128110836 (electronic bk.)