| Description |
1 online resource : illustrations |
| Contents |
Intro; Title page; Table of Contents; Copyright; Dedication; List of Contributors; Biographies; Introduction; Reference; Chapter 1. Sirtuins, NAD+, Aging, and Disease: A Retrospective and Prospective Overview; Abstract; Acknowledgments; Further Reading; Chapter 2. Regulation of Sirtuins by Systemic NAD+ Biosynthesis; Abstract; Acknowledgments; 2.1 Introduction; 2.2 NAD+ Biosynthesis, Consumption, and Degradation; 2.3 The Role of NAD+ Biosynthesis and Sirtuins in Tissue Homeostasis and Disease Conditions |
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2.4 The Concept of the NAD World: The NAMPT/NAD+/SIRT1-Mediated Systemic Regulatory Network for Aging and Longevity Control in Mammals2.5 Concluding Remarks; References; Chapter 3. NAD+ Modulation: Biology and Therapy; Abstract; 3.1 A Bit of History; 3.2 How NAD+ Is Produced; 3.3 NAM, NA, NR, or Tryptophan?; 3.4 Compartmentalization of NAD+ Homeostasis Within the Cell; 3.5 NAD+ as a Regulator of Sirtuin Activity; 3.6 NAD+ Besides Sirtuins; 3.7 NAD+ Boosting Strategies; 3.8 Therapeutic Potential of NAD+ Boosting; 3.9 Conclusion; References; Chapter 4. The Enzymatic Activities of Sirtuins |
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AbstractAcknowledgments; 4.1 Desuccinylation, Demalonylation, and Deglutarylation Catalyzed by SIRT5; 4.2 Hydrolysis of Long-Chain Fatty Acyl Groups (Defatty-Acylation) by Several Sirtuins; 4.3 The Various Deacylation Activities Reported for SIRT4; 4.4 The ADP-Ribosyltransferase Activity of Sirtuins; 4.5 Special Consideration for Sirtuins That Can Recognize Structurally Very Different Acyl Groups; 4.6 Factors That Affect Sirtuin Substrate Specificity; 4.7 Summary and Concluding Remarks; References |
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Chapter 5. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological ModulationAbstract; 5.1 Sirtuin Function, Structure, and Catalytic Mechanism; 5.2 Sirtuin Inhibitors; 5.3 Sirtuin Activators; 5.4 Outlook; References; Chapter 6. Pharmacological Approaches for Modulating Sirtuins; Abstract; 6.1 Introduction; 6.2 Allosteric Activators of Sirtuins; 6.3 Pharmacological Modulation of NAD+; 6.4 Beneficial Health Effects of STACs; 6.5 Beneficial Health Effects of NBMs; 6.6 Conclusions; References; Chapter 7. Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins |
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AbstractAcknowledgments; 7.1 Introduction; 7.2 Enzymatic Activity of the Mitochondrial Sirtuins; 7.3 Proteomic Characterization of Acyl-Lysine Modifications; 7.4 The Roles of Mitochondrial Sirtuins Under Basal Conditions; 7.5 Physiological Roles of Mitochondrial Sirtuins in the Heart; 7.6 Reactive Acyl-CoA Species and Carbon Stress; 7.7 RACS, Metabolism, and Heart Failure; 7.8 Conclusions; References; Chapter 8. Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks; Abstract; 8.1 Introduction; 8.2 SIRT3; 8.3 SIRT4; 8.4 SIRT5 |
| Summary |
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Sirtuins.
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Sirtuins
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SCIENCE -- Chemistry -- Organic.
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Sirtuins
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| Form |
Electronic book
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| Author |
Guarente, Leonard, editor
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Mostoslavsky, Raul, editor
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Kazantsev, Aleksey, editor
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| ISBN |
9780128135006 |
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012813500X |
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